The Etiology of Multiple Sclerosis: Genetic Evidence for the Involvement of the Human Endogenous Retrovirus HERV-Fc1

Bjørn Andersen Nexø, Tove Christensen, Jette Frederiksen, Anné Møller-Larsen, Annette Bang Oturai, Palle Villesen, Bettina Hansen, Kari K Nissen, Magdalena J Laska, Trine Skov Petersen, Sandra Bonnesen, Anne Hedemand, Tingting Wu, Xinjie Wang, Xiuqing Zhang, Tomasz Brudek, Romana Maric, Helle Søndergaard, Finn Thorup Sellebjerg, Klaus BrusgaardAnders L Kjeldbjerg, Henrik B Rasmussen, Anders L Nielsen, Mette Nyegaard, Thor Petersen, Anders D Børglum, Finn S Pedersen

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Abstract

We have investigated the role of human endogenous retroviruses in multiple sclerosis by analyzing the DNA of patients and controls in 4 cohorts for associations between multiple sclerosis and polymorphisms near viral restriction genes or near endogenous retroviral loci with one or more intact or almost-intact genes. We found that SNPs in the gene TRIM5 were inversely correlated with disease. Conversely, SNPs around one retroviral locus, HERV-Fc1, showed a highly significant association with disease. The latter association was limited to a narrow region that contains no other known genes. We conclude that HERV-Fc1 and TRIM5 play a role in the etiology of multiple sclerosis. If these results are confirmed, they point to new modes of treatment for multiple sclerosis.
Original languageEnglish
JournalP L o S One
Volume6
Issue2
Pages (from-to)e16652
ISSN1932-6203
DOIs
Publication statusPublished - 1 Jan 2011

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