Abstract
Introduction: Up to 20% of patients undergoing total knee replacement (TKR) surgery report no or suboptimal pain relief. Despite chances of recovering to preoperative functional levels, patients receiving TKR have demonstrated persistent deficits in strength and functional performance.
Low-load blood flow restricted resistance exercise (BFRE) has been documented to promote skeletal muscle hypertrophy and strength, despite the low magnitude of mechanical stress imposed on the trained tissue. High-frequency BFRE have previously promoted muscle fiber satellite cell- and myonuclei content which might represent an atrophy-protective mechanism.
Purpose: The purpose is to examine 1) the efficacy of preoperative BFRE on postoperative function, lower-limb strength and self-reported outcomes 2) to which extent preoperative BFRE will protect against surgery-related atrophy 3 months after TKR.
The primary aim of this trial is to examine the efficacy 8 weeks of low-load BFRE prior to a scheduled TKR on changes in 30-seconds Chair stand test from baseline to 3 months postoperatively.
Methods:The trial is a multicenter, randomized controlled and assessor blinded trial. Patients scheduled for TKR will be randomized to 8 weeks of BFRE or following usual care before TKR. Data will be collected at baseline, in the week of TKR, 3 and 12 months postoperatively.
Conclusion: This is the first trial to investigate the efficacy of preoperative BFRE on functional capacity, self-reported outcome, lower limb muscle strength and myofiber morphology/stem cell abundance in patients scheduled for TKR.
Low-load blood flow restricted resistance exercise (BFRE) has been documented to promote skeletal muscle hypertrophy and strength, despite the low magnitude of mechanical stress imposed on the trained tissue. High-frequency BFRE have previously promoted muscle fiber satellite cell- and myonuclei content which might represent an atrophy-protective mechanism.
Purpose: The purpose is to examine 1) the efficacy of preoperative BFRE on postoperative function, lower-limb strength and self-reported outcomes 2) to which extent preoperative BFRE will protect against surgery-related atrophy 3 months after TKR.
The primary aim of this trial is to examine the efficacy 8 weeks of low-load BFRE prior to a scheduled TKR on changes in 30-seconds Chair stand test from baseline to 3 months postoperatively.
Methods:The trial is a multicenter, randomized controlled and assessor blinded trial. Patients scheduled for TKR will be randomized to 8 weeks of BFRE or following usual care before TKR. Data will be collected at baseline, in the week of TKR, 3 and 12 months postoperatively.
Conclusion: This is the first trial to investigate the efficacy of preoperative BFRE on functional capacity, self-reported outcome, lower limb muscle strength and myofiber morphology/stem cell abundance in patients scheduled for TKR.
| Original language | Danish |
|---|---|
| Publication date | 22 Jan 2021 |
| Number of pages | 1 |
| Publication status | Published - 22 Jan 2021 |
| Event | PhD Day 2020 - Aarhus Universitet, Aarhus, Denmark Duration: 24 Jan 2020 → 24 Jan 2020 |
Conference
| Conference | PhD Day 2020 |
|---|---|
| Location | Aarhus Universitet |
| Country/Territory | Denmark |
| City | Aarhus |
| Period | 24/01/2020 → 24/01/2020 |