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The effects of microgravity on differentiation and cell growth in stem cells and cancer stem cells

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  • Daniela Grimm
  • Markus Wehland
  • Thomas J Corydon
  • Peter Richter, a Department of Biology, Cell Biology , Friedrich-Alexander-University Erlangen-Nuremberg , 91058 Erlangen , Germany.
  • ,
  • Binod Prasad, a Department of Biology, Cell Biology , Friedrich-Alexander-University Erlangen-Nuremberg , 91058 Erlangen , Germany.
  • ,
  • Johann Bauer, Max-Planck-Institute for Biochemistry Martinsried, 82152 Planegg, Germany. jbauer@biochem.mpg.de.
  • ,
  • Marcel Egli, Lucerne University of Applied Sciences and Arts
  • ,
  • Sascha Kopp, Otto von Guericke University Magdeburg
  • ,
  • Michael Lebert, Space Biology Unlimited SAS, Bordeaux, France.
  • ,
  • Marcus Krüger, Otto von Guericke University Magdeburg

A spaceflight has enormous influence on the health of space voyagers due to the combined effects of microgravity and cosmic radiation. Known effects of microgravity (μg) on cells are changes in differentiation and growth. Considering the commercialization of spaceflight, future space exploration, and long-term manned flights, research focusing on differentiation and growth of stem cells and cancer cells exposed to real (r-) and simulated (s-) μg is of high interest for regenerative medicine and cancer research. In this review, we focus on platforms to study r- and s-μg as well as the impact of μg on cancer stem cells in the field of gastrointestinal cancer, lung cancer, and osteosarcoma. Moreover, we review the current knowledge of different types of stem cells exposed to μg conditions with regard to differentiation and engineering of cartilage, bone, vasculature, heart, skin, and liver constructs.

Original languageEnglish
JournalStem Cells Translational Medicine
Pages (from-to)882-894
Number of pages13
Publication statusPublished - 2020

Bibliographical note

© 2020 The Authors. STEM CELLS TRANSLATIONAL MEDICINE published by Wiley Periodicals, Inc. on behalf of AlphaMed Press.

    Research areas

  • cancer stem cells, microgravity, multicellular spheroids, organoids, random positioning machine, rotating wall vessel, spaceflight, stem cells, tissue engineering

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