The Effects of Micro- and Nano-Topography on Cells

Research output: Book/anthology/dissertation/reportPh.D. thesisResearch

  • Kristian Kolind, Denmark
Cells continuously make decisions on what proteins to express, and when to divide, differentiate and commit suicide, through a complex network of intracellular processes. The signals that determine the cellular processes reside within the extracellular matrix. They involve soluble signaling molecules and insoluble protein structures that act in a finely coordinated manner to direct cell fate. The insoluble protein structures possess physical and chemical characteristics that guide cells, an important one being topography at the micro- and nano-length scale. Research performed regarding the effect of topography on cells has received much attention understanding how important this is for the rational design of bio-interfaces. Nevertheless, there is still a limited understanding of the effect of topography on cells making it impossible to tailor a biomaterial with specific cellular activity at the substrate surface. The major aim of this PhD thesis has been to understand the effect of micro- and nano-topography on focal adhesion assembly and cell spreading, as well as its effect on proliferation and differentiation of cells. Such knowledge will provide a more rational approach to optimize the function of next generation implants, and to build proper surfaces for tissue engineering applications.
Original languageEnglish
Publication statusPublished - 2013

See relations at Aarhus University Citationformats

ID: 51542749