The effect of transcervical endometrial resection on clinical symptoms related to intrinsic adenomyosis and junctional zone changes

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The effect of transcervical endometrial resection on clinical symptoms related to intrinsic adenomyosis and junctional zone changes. / Rasmussen, Christina K.; Hansen, Estrid S.; Al-Mashadi Dahl, Sham et al.

In: European Journal of Obstetrics & Gynecology and Reproductive Biology, Vol. 3, 100029, 01.07.2019.

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Rasmussen, Christina K. ; Hansen, Estrid S. ; Al-Mashadi Dahl, Sham et al. / The effect of transcervical endometrial resection on clinical symptoms related to intrinsic adenomyosis and junctional zone changes. In: European Journal of Obstetrics & Gynecology and Reproductive Biology. 2019 ; Vol. 3.

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@article{4fc3dc979a584b43ac7713ed018011a3,
title = "The effect of transcervical endometrial resection on clinical symptoms related to intrinsic adenomyosis and junctional zone changes",
abstract = "Objectives: To assess the effect of transcervical endometrial resection on clinical symptoms related to histopathological findings of the junctional zone. Study design: This prospective study took place at a university hospital. Premenopausal women suffering from abnormal uterine bleeding and/or pelvic pain and scheduled for transcervical endometrial resection were enrolled (n = 112). Histopathological findings of the endomyometrial biopsies were categorized as follows: Adenomyosis of the inner myometrium (intrinsic adenomyosis): ≥ 2 mm myometrial invasion without contact to the basal endometrium, serrated junctional zone: > 3 mm myometrial invasion with contact to the basal endometrium and linear junctional zone: No or marginal myometrial invasion (≤ 3 mm)with contact to the basal endometrium. All study participants received a baseline and two follow-up questionnaires (6 and 18 months after surgery)regarding symptom severity, health-related quality of life and pelvic pain. Data regarding reintervention surgery was obtained from the National Database Patoweb. The rate of reintervention surgery and the improvement in symptom severity, health-related quality of life and pelvic pain were correlated to histopathological findings. Results: Twenty-four patients had intrinsic adenomyosis, 31 had serrated junctional zone and 57 had linear junctional zone. Fifteen patients (13%)underwent reintervention surgery; three (20%)within 6 months, nine (60%)between 6–18 months and three (20%)> 18 months after transcervical endometrial resection. Reintervention surgery was more common in women with intrinsic adenomyosis compared to women without (33% (95% CI: 16–55)vs 8% (95% CI: 3–16))(p-value: <.05). Nine patients (38%)with intrinsic adenomyosis were asymptomatic based on low symptom severity score, high health-related quality of life and no pelvic pain at 18 months follow-up. Patients with linear junctional zone had a higher improvement in symptom severity and health-related quality of life than patients with intrinsic adenomyosis or serrated junctional zone at 6 months follow-up after surgery (p-value <.05). However, there was no significant difference in pelvic pain reduction. Conclusion: The effect of transcervical endometrial resection may depend upon the degree of junctional zone changes, and patients with intrinsic adenomyosis are more likely to undergo reintervention surgery than patients with either linear or serrated junctional zone. However, intrinsic adenomyosis may also be successfully treated with endometrial resection.",
keywords = "Adenomyosis, Health-related quality of life, Heavy menstrual bleeding, Pelvic pain",
author = "Rasmussen, {Christina K.} and Hansen, {Estrid S.} and {Al-Mashadi Dahl}, Sham and Erik Ernst and Margit Dueholm",
year = "2019",
month = jul,
day = "1",
doi = "10.1016/j.eurox.2019.100029",
language = "English",
volume = "3",
journal = "European Journal of Obstetrics & Gynecology and Reproductive Biology",
issn = "0301-2115",
publisher = "Elsevier Ireland Ltd.",

}

RIS

TY - JOUR

T1 - The effect of transcervical endometrial resection on clinical symptoms related to intrinsic adenomyosis and junctional zone changes

AU - Rasmussen, Christina K.

AU - Hansen, Estrid S.

AU - Al-Mashadi Dahl, Sham

AU - Ernst, Erik

AU - Dueholm, Margit

PY - 2019/7/1

Y1 - 2019/7/1

N2 - Objectives: To assess the effect of transcervical endometrial resection on clinical symptoms related to histopathological findings of the junctional zone. Study design: This prospective study took place at a university hospital. Premenopausal women suffering from abnormal uterine bleeding and/or pelvic pain and scheduled for transcervical endometrial resection were enrolled (n = 112). Histopathological findings of the endomyometrial biopsies were categorized as follows: Adenomyosis of the inner myometrium (intrinsic adenomyosis): ≥ 2 mm myometrial invasion without contact to the basal endometrium, serrated junctional zone: > 3 mm myometrial invasion with contact to the basal endometrium and linear junctional zone: No or marginal myometrial invasion (≤ 3 mm)with contact to the basal endometrium. All study participants received a baseline and two follow-up questionnaires (6 and 18 months after surgery)regarding symptom severity, health-related quality of life and pelvic pain. Data regarding reintervention surgery was obtained from the National Database Patoweb. The rate of reintervention surgery and the improvement in symptom severity, health-related quality of life and pelvic pain were correlated to histopathological findings. Results: Twenty-four patients had intrinsic adenomyosis, 31 had serrated junctional zone and 57 had linear junctional zone. Fifteen patients (13%)underwent reintervention surgery; three (20%)within 6 months, nine (60%)between 6–18 months and three (20%)> 18 months after transcervical endometrial resection. Reintervention surgery was more common in women with intrinsic adenomyosis compared to women without (33% (95% CI: 16–55)vs 8% (95% CI: 3–16))(p-value: <.05). Nine patients (38%)with intrinsic adenomyosis were asymptomatic based on low symptom severity score, high health-related quality of life and no pelvic pain at 18 months follow-up. Patients with linear junctional zone had a higher improvement in symptom severity and health-related quality of life than patients with intrinsic adenomyosis or serrated junctional zone at 6 months follow-up after surgery (p-value <.05). However, there was no significant difference in pelvic pain reduction. Conclusion: The effect of transcervical endometrial resection may depend upon the degree of junctional zone changes, and patients with intrinsic adenomyosis are more likely to undergo reintervention surgery than patients with either linear or serrated junctional zone. However, intrinsic adenomyosis may also be successfully treated with endometrial resection.

AB - Objectives: To assess the effect of transcervical endometrial resection on clinical symptoms related to histopathological findings of the junctional zone. Study design: This prospective study took place at a university hospital. Premenopausal women suffering from abnormal uterine bleeding and/or pelvic pain and scheduled for transcervical endometrial resection were enrolled (n = 112). Histopathological findings of the endomyometrial biopsies were categorized as follows: Adenomyosis of the inner myometrium (intrinsic adenomyosis): ≥ 2 mm myometrial invasion without contact to the basal endometrium, serrated junctional zone: > 3 mm myometrial invasion with contact to the basal endometrium and linear junctional zone: No or marginal myometrial invasion (≤ 3 mm)with contact to the basal endometrium. All study participants received a baseline and two follow-up questionnaires (6 and 18 months after surgery)regarding symptom severity, health-related quality of life and pelvic pain. Data regarding reintervention surgery was obtained from the National Database Patoweb. The rate of reintervention surgery and the improvement in symptom severity, health-related quality of life and pelvic pain were correlated to histopathological findings. Results: Twenty-four patients had intrinsic adenomyosis, 31 had serrated junctional zone and 57 had linear junctional zone. Fifteen patients (13%)underwent reintervention surgery; three (20%)within 6 months, nine (60%)between 6–18 months and three (20%)> 18 months after transcervical endometrial resection. Reintervention surgery was more common in women with intrinsic adenomyosis compared to women without (33% (95% CI: 16–55)vs 8% (95% CI: 3–16))(p-value: <.05). Nine patients (38%)with intrinsic adenomyosis were asymptomatic based on low symptom severity score, high health-related quality of life and no pelvic pain at 18 months follow-up. Patients with linear junctional zone had a higher improvement in symptom severity and health-related quality of life than patients with intrinsic adenomyosis or serrated junctional zone at 6 months follow-up after surgery (p-value <.05). However, there was no significant difference in pelvic pain reduction. Conclusion: The effect of transcervical endometrial resection may depend upon the degree of junctional zone changes, and patients with intrinsic adenomyosis are more likely to undergo reintervention surgery than patients with either linear or serrated junctional zone. However, intrinsic adenomyosis may also be successfully treated with endometrial resection.

KW - Adenomyosis

KW - Health-related quality of life

KW - Heavy menstrual bleeding

KW - Pelvic pain

UR - http://www.scopus.com/inward/record.url?scp=85065848443&partnerID=8YFLogxK

U2 - 10.1016/j.eurox.2019.100029

DO - 10.1016/j.eurox.2019.100029

M3 - Journal article

C2 - 31404400

AN - SCOPUS:85065848443

VL - 3

JO - European Journal of Obstetrics & Gynecology and Reproductive Biology

JF - European Journal of Obstetrics & Gynecology and Reproductive Biology

SN - 0301-2115

M1 - 100029

ER -