The effect of the nitric oxide donor glyceryl trinitrate on global and regional cerebral blood flow in man

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  • R. P. White, King's College London
  • ,
  • C. Deane, King's College London
  • ,
  • C. Hindley, Hammersmith Hospital
  • ,
  • P. M. Bloomfield, Hammersmith Hospital
  • ,
  • V. J. Cunningham, Hammersmith Hospital
  • ,
  • P. Vallance, Wolfson Inst. Biochem. Res.
  • ,
  • D. J. Brooks
  • H. S. Markus, King's College London

Despite their potential use as cerebral vasodilatory agents there are few studies of the effect of nitric oxide (NO) donors on the cerebral circulation in non-anaesthetised man. We determined the effect of the NO donor glyceryl trinitrate (GTN) at clinically relevant doses on global and regional cerebral blood flow (CBF) in healthy non-anaesthetised volunteers, using H2/15O PET, ultrasonic colour velocity flow imaging of carotid artery flow, and transcranial Doppler (TCD) of middle cerebral artery velocities (MCAv). Three rates of GTN infusion (0.1, 0.4, 1.0 μg/kg/min) were used. There was no significant change in common or internal carotid artery flow following GTN administration although a dose dependent fall in MCAv post GTN was observed. There was no significant change in either global or regional CBF following GTN. Thus intravenous GTN at therapeutic doses in awake humans does not alter global or regional CBF. However it does produce basal cerebral artery vasodilatation as evidenced by a fall in MCAv in the absence of a change in internal carotid artery flow. (C) 2000 Elsevier Science B.V.

Original languageEnglish
JournalJournal of the Neurological Sciences
Pages (from-to)23-28
Number of pages6
Publication statusPublished - 1 Sep 2000
Externally publishedYes

    Research areas

  • Cerebral blood flow, Glyceryl trinitrate, Man, Nitric oxide, Positron emission tomography, Ultrasonics

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