The effect of gestational age on major neurodevelopmental disorders in preterm infants

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The effect of gestational age on major neurodevelopmental disorders in preterm infants. / Larsen, Mads L.; Wiingreen, Rikke; Jensen, Andreas et al.

In: Pediatric Research, Vol. 91, No. 7, 06.2022, p. 1906-1912.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Larsen, ML, Wiingreen, R, Jensen, A, Rackauskaite, G, Laursen, B, Hansen, BM, Hoei-Hansen, CE & Greisen, G 2022, 'The effect of gestational age on major neurodevelopmental disorders in preterm infants', Pediatric Research, vol. 91, no. 7, pp. 1906-1912. https://doi.org/10.1038/s41390-021-01710-4

APA

Larsen, M. L., Wiingreen, R., Jensen, A., Rackauskaite, G., Laursen, B., Hansen, B. M., Hoei-Hansen, C. E., & Greisen, G. (2022). The effect of gestational age on major neurodevelopmental disorders in preterm infants. Pediatric Research, 91(7), 1906-1912. https://doi.org/10.1038/s41390-021-01710-4

CBE

Larsen ML, Wiingreen R, Jensen A, Rackauskaite G, Laursen B, Hansen BM, Hoei-Hansen CE, Greisen G. 2022. The effect of gestational age on major neurodevelopmental disorders in preterm infants. Pediatric Research. 91(7):1906-1912. https://doi.org/10.1038/s41390-021-01710-4

MLA

Vancouver

Larsen ML, Wiingreen R, Jensen A, Rackauskaite G, Laursen B, Hansen BM et al. The effect of gestational age on major neurodevelopmental disorders in preterm infants. Pediatric Research. 2022 Jun;91(7):1906-1912. doi: 10.1038/s41390-021-01710-4

Author

Larsen, Mads L. ; Wiingreen, Rikke ; Jensen, Andreas et al. / The effect of gestational age on major neurodevelopmental disorders in preterm infants. In: Pediatric Research. 2022 ; Vol. 91, No. 7. pp. 1906-1912.

Bibtex

@article{718a97c478c14165930992352106ff01,
title = "The effect of gestational age on major neurodevelopmental disorders in preterm infants",
abstract = "Background: Preterm infants have an increased risk of neurodevelopmental disorders. We established a direct quantitative comparison of the association between the degree of prematurity and three different neurodevelopmental disorders. Methods: In this cohort study, we combined data from 995,498 children in the Danish Medical Birth Register, from birth years 1997–2013, with information on cerebral palsy, epilepsy, and special educational needs. We estimated the gestational week-specific prevalence and risk for each of the disorders. Results: The risk ratio of cerebral palsy at gestational weeks 21–24, compared to term birth, was more than ten times higher than for the two other disorders. The prevalence of epilepsy and special educational needs declined almost parallel, with 9.2% (4.6%–13.5%) and 12.5% (11.2%–13.7%), respectively, per week of gestation toward term birth. Cerebral palsy did not decline similarly: from gestational weeks 21–24 until week 29 the prevalence declined insignificantly by 0.6% (−11.1%–11.0%) per week; whereas from week 29 until term, the prevalence declined markedly by 36.7% (25.9%–45.9%) per week. Conclusions: The prevalence and risk of cerebral palsy are affected differently by the degree of prematurity compared with epilepsy and special educational needs, possibly reflecting important differences in cerebral pathophysiology. Impact: For each week of gestation toward term birth, there was a clear log-linear decline in the prevalence of early childhood epilepsy and special educational needs.In contrast, the risk of cerebral palsy was high at the earliest gestational age, and the prevalence did not decline significantly until gestational week 29, from where it declined notably by nearly 40% for each week of gestation until term birth.Our results indicate important differences in the pathophysiological processes that associate preterm birth with these three neurodevelopmental disorders.",
author = "Larsen, {Mads L.} and Rikke Wiingreen and Andreas Jensen and Gija Rackauskaite and Bjarne Laursen and Hansen, {Bo M.} and Hoei-Hansen, {Christina E.} and Gorm Greisen",
note = "Publisher Copyright: {\textcopyright} 2021, The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc.",
year = "2022",
month = jun,
doi = "10.1038/s41390-021-01710-4",
language = "English",
volume = "91",
pages = "1906--1912",
journal = "Pediatric Research",
issn = "0031-3998",
publisher = "Nature Publishing Group",
number = "7",

}

RIS

TY - JOUR

T1 - The effect of gestational age on major neurodevelopmental disorders in preterm infants

AU - Larsen, Mads L.

AU - Wiingreen, Rikke

AU - Jensen, Andreas

AU - Rackauskaite, Gija

AU - Laursen, Bjarne

AU - Hansen, Bo M.

AU - Hoei-Hansen, Christina E.

AU - Greisen, Gorm

N1 - Publisher Copyright: © 2021, The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc.

PY - 2022/6

Y1 - 2022/6

N2 - Background: Preterm infants have an increased risk of neurodevelopmental disorders. We established a direct quantitative comparison of the association between the degree of prematurity and three different neurodevelopmental disorders. Methods: In this cohort study, we combined data from 995,498 children in the Danish Medical Birth Register, from birth years 1997–2013, with information on cerebral palsy, epilepsy, and special educational needs. We estimated the gestational week-specific prevalence and risk for each of the disorders. Results: The risk ratio of cerebral palsy at gestational weeks 21–24, compared to term birth, was more than ten times higher than for the two other disorders. The prevalence of epilepsy and special educational needs declined almost parallel, with 9.2% (4.6%–13.5%) and 12.5% (11.2%–13.7%), respectively, per week of gestation toward term birth. Cerebral palsy did not decline similarly: from gestational weeks 21–24 until week 29 the prevalence declined insignificantly by 0.6% (−11.1%–11.0%) per week; whereas from week 29 until term, the prevalence declined markedly by 36.7% (25.9%–45.9%) per week. Conclusions: The prevalence and risk of cerebral palsy are affected differently by the degree of prematurity compared with epilepsy and special educational needs, possibly reflecting important differences in cerebral pathophysiology. Impact: For each week of gestation toward term birth, there was a clear log-linear decline in the prevalence of early childhood epilepsy and special educational needs.In contrast, the risk of cerebral palsy was high at the earliest gestational age, and the prevalence did not decline significantly until gestational week 29, from where it declined notably by nearly 40% for each week of gestation until term birth.Our results indicate important differences in the pathophysiological processes that associate preterm birth with these three neurodevelopmental disorders.

AB - Background: Preterm infants have an increased risk of neurodevelopmental disorders. We established a direct quantitative comparison of the association between the degree of prematurity and three different neurodevelopmental disorders. Methods: In this cohort study, we combined data from 995,498 children in the Danish Medical Birth Register, from birth years 1997–2013, with information on cerebral palsy, epilepsy, and special educational needs. We estimated the gestational week-specific prevalence and risk for each of the disorders. Results: The risk ratio of cerebral palsy at gestational weeks 21–24, compared to term birth, was more than ten times higher than for the two other disorders. The prevalence of epilepsy and special educational needs declined almost parallel, with 9.2% (4.6%–13.5%) and 12.5% (11.2%–13.7%), respectively, per week of gestation toward term birth. Cerebral palsy did not decline similarly: from gestational weeks 21–24 until week 29 the prevalence declined insignificantly by 0.6% (−11.1%–11.0%) per week; whereas from week 29 until term, the prevalence declined markedly by 36.7% (25.9%–45.9%) per week. Conclusions: The prevalence and risk of cerebral palsy are affected differently by the degree of prematurity compared with epilepsy and special educational needs, possibly reflecting important differences in cerebral pathophysiology. Impact: For each week of gestation toward term birth, there was a clear log-linear decline in the prevalence of early childhood epilepsy and special educational needs.In contrast, the risk of cerebral palsy was high at the earliest gestational age, and the prevalence did not decline significantly until gestational week 29, from where it declined notably by nearly 40% for each week of gestation until term birth.Our results indicate important differences in the pathophysiological processes that associate preterm birth with these three neurodevelopmental disorders.

UR - http://www.scopus.com/inward/record.url?scp=85113794133&partnerID=8YFLogxK

U2 - 10.1038/s41390-021-01710-4

DO - 10.1038/s41390-021-01710-4

M3 - Journal article

C2 - 34420036

AN - SCOPUS:85113794133

VL - 91

SP - 1906

EP - 1912

JO - Pediatric Research

JF - Pediatric Research

SN - 0031-3998

IS - 7

ER -