The effect of crack cocaine addiction on the microstructure and morphology of the human striatum and thalamus using novel shape analysis and fast diffusion kurtosis imaging.

Eduardo A. Garza-Villarreal; Chakravarty Mallar; Brian Hansen; Simon Fristed Eskildsen; Gabriel A. Devenyi; Diana Castillo-Padilla; Thania Balducci-Garcia; Ernesto Reyes-Zamorano; Sune Nørhøj Jespersen; Pamela Perez-Palacios; Raihaan Patel; Jorge J. Gonzalez-Olvera

doi:10.1101/066647

The effect of crack cocaine addiction on the microstructure and morphology of the human striatum and thalamus using novel shape analysis and fast diffusion kurtosis imaging.

Eduardo A. Garza-Villarreal, Chakravarty Mallar, Brian Hansen, Simon Fristed Eskildsen, Gabriel A. Devenyi, Diana Castillo-Padilla, Thania Balducci-Garcia, Ernesto Reyes-Zamorano, Sune Nørhøj Jespersen, Pamela Perez-Palacios, Raihaan Patel, Jorge J. Gonzalez-Olvera

Research output: Working paper/Preprint › Preprint

Abstract

The striatum and thalamus are subcortical structures intimately involved in addiction, and the morphology and microstructure of these has been studied in murine models of cocaine addiction. However, human studies using non-invasive MRI has shown inconsistencies in morphology using volumetric analysis. In our study, we used MRI-based volumetric and novel shape analysis, as well as a novel fast diffusion kurtosis imaging sequence to study the morphology and microstructure of striatum and thalamus in crack cocaine addiction (CA) compared to matched healthy controls (HC). We did not find significant differences in volume and mean kurtosis (MKT) between groups. However, we found significant contraction of nucleus accumbens in CA compared to HC. We also found significant age related changes in volume and MKT of CA in striatum and thalamus that are contrary to those seen in normal brain aging. Our findings suggest that the use of finer methods and sequences is needed to characterize morphological and microstructural changes in cocaine addiction, and that brain changes in cocaine addiction are related to age.

Original language	English
Edition	066647
DOIs	https://doi.org/10.1101/066647
Publication status	Published - 29 Jul 2016

Keywords

Addiction
MORPHOLOGY
Cocaine-Related Disorders
MRI

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10.1101/066647Licence: CC BY-NC

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Garza-Villarreal, E. A., Mallar, C., Hansen, B., Eskildsen, S. F., Devenyi, G. A., Castillo-Padilla, D., Balducci-Garcia, T., Reyes-Zamorano, E., Jespersen, S. N., Perez-Palacios, P., Patel, R., & Gonzalez-Olvera, J. J. (2016). The effect of crack cocaine addiction on the microstructure and morphology of the human striatum and thalamus using novel shape analysis and fast diffusion kurtosis imaging. (066647 ed.) https://doi.org/10.1101/066647

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title = "The effect of crack cocaine addiction on the microstructure and morphology of the human striatum and thalamus using novel shape analysis and fast diffusion kurtosis imaging.",

abstract = "The striatum and thalamus are subcortical structures intimately involved in addiction, and the morphology and microstructure of these has been studied in murine models of cocaine addiction. However, human studies using non-invasive MRI has shown inconsistencies in morphology using volumetric analysis. In our study, we used MRI-based volumetric and novel shape analysis, as well as a novel fast diffusion kurtosis imaging sequence to study the morphology and microstructure of striatum and thalamus in crack cocaine addiction (CA) compared to matched healthy controls (HC). We did not find significant differences in volume and mean kurtosis (MKT) between groups. However, we found significant contraction of nucleus accumbens in CA compared to HC. We also found significant age related changes in volume and MKT of CA in striatum and thalamus that are contrary to those seen in normal brain aging. Our findings suggest that the use of finer methods and sequences is needed to characterize morphological and microstructural changes in cocaine addiction, and that brain changes in cocaine addiction are related to age.",

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Garza-Villarreal, EA, Mallar, C, Hansen, B , Eskildsen, SF, Devenyi, GA, Castillo-Padilla, D, Balducci-Garcia, T, Reyes-Zamorano, E, Jespersen, SN, Perez-Palacios, P, Patel, R & Gonzalez-Olvera, JJ 2016 'The effect of crack cocaine addiction on the microstructure and morphology of the human striatum and thalamus using novel shape analysis and fast diffusion kurtosis imaging.' 066647 edn. https://doi.org/10.1101/066647

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T1 - The effect of crack cocaine addiction on the microstructure and morphology of the human striatum and thalamus using novel shape analysis and fast diffusion kurtosis imaging.

AU - Garza-Villarreal, Eduardo A.

AU - Mallar, Chakravarty

AU - Hansen, Brian

AU - Eskildsen, Simon Fristed

AU - Devenyi, Gabriel A.

AU - Castillo-Padilla, Diana

AU - Balducci-Garcia, Thania

AU - Reyes-Zamorano, Ernesto

AU - Jespersen, Sune Nørhøj

AU - Perez-Palacios, Pamela

AU - Patel, Raihaan

AU - Gonzalez-Olvera, Jorge J.

N1 - PREPRINT

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N2 - The striatum and thalamus are subcortical structures intimately involved in addiction, and the morphology and microstructure of these has been studied in murine models of cocaine addiction. However, human studies using non-invasive MRI has shown inconsistencies in morphology using volumetric analysis. In our study, we used MRI-based volumetric and novel shape analysis, as well as a novel fast diffusion kurtosis imaging sequence to study the morphology and microstructure of striatum and thalamus in crack cocaine addiction (CA) compared to matched healthy controls (HC). We did not find significant differences in volume and mean kurtosis (MKT) between groups. However, we found significant contraction of nucleus accumbens in CA compared to HC. We also found significant age related changes in volume and MKT of CA in striatum and thalamus that are contrary to those seen in normal brain aging. Our findings suggest that the use of finer methods and sequences is needed to characterize morphological and microstructural changes in cocaine addiction, and that brain changes in cocaine addiction are related to age.

AB - The striatum and thalamus are subcortical structures intimately involved in addiction, and the morphology and microstructure of these has been studied in murine models of cocaine addiction. However, human studies using non-invasive MRI has shown inconsistencies in morphology using volumetric analysis. In our study, we used MRI-based volumetric and novel shape analysis, as well as a novel fast diffusion kurtosis imaging sequence to study the morphology and microstructure of striatum and thalamus in crack cocaine addiction (CA) compared to matched healthy controls (HC). We did not find significant differences in volume and mean kurtosis (MKT) between groups. However, we found significant contraction of nucleus accumbens in CA compared to HC. We also found significant age related changes in volume and MKT of CA in striatum and thalamus that are contrary to those seen in normal brain aging. Our findings suggest that the use of finer methods and sequences is needed to characterize morphological and microstructural changes in cocaine addiction, and that brain changes in cocaine addiction are related to age.

KW - Addiction

KW - MORPHOLOGY

KW - Cocaine-Related Disorders

KW - MRI

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M3 - Preprint

BT - The effect of crack cocaine addiction on the microstructure and morphology of the human striatum and thalamus using novel shape analysis and fast diffusion kurtosis imaging.

ER -

The effect of crack cocaine addiction on the microstructure and morphology of the human striatum and thalamus using novel shape analysis and fast diffusion kurtosis imaging.

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Keywords

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