Department of Economics and Business Economics

The Eating Disorders Genetics Initiative (EDGI): study protocol

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

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The Eating Disorders Genetics Initiative (EDGI) : study protocol. / Bulik, Cynthia M; Thornton, Laura M; Parker, Richard; Kennedy, Hannah; Baker, Jessica H; MacDermod, Casey; Guintivano, Jerry; Cleland, Lana; Miller, Allison L; Harper, Lauren; Larsen, Janne T; Yilmaz, Zeynep; Grove, Jakob; Sullivan, Patrick F; Petersen, Liselotte V; Jordan, Jennifer; Kennedy, Martin A; Martin, Nicholas G.

In: BMC Psychiatry, Vol. 21, 234, 05.2021.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Bulik, CM, Thornton, LM, Parker, R, Kennedy, H, Baker, JH, MacDermod, C, Guintivano, J, Cleland, L, Miller, AL, Harper, L, Larsen, JT, Yilmaz, Z, Grove, J, Sullivan, PF, Petersen, LV, Jordan, J, Kennedy, MA & Martin, NG 2021, 'The Eating Disorders Genetics Initiative (EDGI): study protocol', BMC Psychiatry, vol. 21, 234. https://doi.org/10.1186/s12888-021-03212-3

APA

Bulik, C. M., Thornton, L. M., Parker, R., Kennedy, H., Baker, J. H., MacDermod, C., Guintivano, J., Cleland, L., Miller, A. L., Harper, L., Larsen, J. T., Yilmaz, Z., Grove, J., Sullivan, P. F., Petersen, L. V., Jordan, J., Kennedy, M. A., & Martin, N. G. (2021). The Eating Disorders Genetics Initiative (EDGI): study protocol. BMC Psychiatry, 21, [234]. https://doi.org/10.1186/s12888-021-03212-3

CBE

Bulik CM, Thornton LM, Parker R, Kennedy H, Baker JH, MacDermod C, Guintivano J, Cleland L, Miller AL, Harper L, Larsen JT, Yilmaz Z, Grove J, Sullivan PF, Petersen LV, Jordan J, Kennedy MA, Martin NG. 2021. The Eating Disorders Genetics Initiative (EDGI): study protocol. BMC Psychiatry. 21:Article 234. https://doi.org/10.1186/s12888-021-03212-3

MLA

Vancouver

Bulik CM, Thornton LM, Parker R, Kennedy H, Baker JH, MacDermod C et al. The Eating Disorders Genetics Initiative (EDGI): study protocol. BMC Psychiatry. 2021 May;21. 234. https://doi.org/10.1186/s12888-021-03212-3

Author

Bulik, Cynthia M ; Thornton, Laura M ; Parker, Richard ; Kennedy, Hannah ; Baker, Jessica H ; MacDermod, Casey ; Guintivano, Jerry ; Cleland, Lana ; Miller, Allison L ; Harper, Lauren ; Larsen, Janne T ; Yilmaz, Zeynep ; Grove, Jakob ; Sullivan, Patrick F ; Petersen, Liselotte V ; Jordan, Jennifer ; Kennedy, Martin A ; Martin, Nicholas G. / The Eating Disorders Genetics Initiative (EDGI) : study protocol. In: BMC Psychiatry. 2021 ; Vol. 21.

Bibtex

@article{89dccb68c103469a85a46bbbf4db7b9a,
title = "The Eating Disorders Genetics Initiative (EDGI): study protocol",
abstract = "BACKGROUND: The Eating Disorders Genetics Initiative (EDGI) is an international investigation exploring the role of genes and environment in anorexia nervosa, bulimia nervosa, and binge-eating disorder.METHODS: A total of 14,500 individuals with eating disorders and 1500 controls will be included from the United States (US), Australia (AU), New Zealand (NZ), and Denmark (DK). In the US, AU, and NZ, participants will complete comprehensive online phenotyping and will submit a saliva sample for genotyping. In DK, individuals with eating disorders will be identified by the National Patient Register, and genotyping will occur using bloodspots archived from birth. A genome-wide association study will be conducted within EDGI and via meta-analysis with other data from the Eating Disorders Working Group of the Psychiatric Genomics Consortium (PGC-ED).DISCUSSION: EDGI represents the largest genetic study of eating disorders ever to be conducted and is designed to rapidly advance the study of the genetics of the three major eating disorders (anorexia nervosa, bulimia nervosa, and binge-eating disorder). We will explicate the genetic architecture of eating disorders relative to each other and to other psychiatric and metabolic disorders and traits. Our goal is for EDGI to deliver {"}actionable{"} findings that can be transformed into clinically meaningful insights.TRIAL REGISTRATION: EDGI is a registered clinical trial: clinicaltrials.gov NCT04378101 .",
keywords = "Australia, Bulimia Nervosa/genetics, Feeding and Eating Disorders/genetics, Genome-Wide Association Study, Humans, Meta-Analysis as Topic, New Zealand, United States",
author = "Bulik, {Cynthia M} and Thornton, {Laura M} and Richard Parker and Hannah Kennedy and Baker, {Jessica H} and Casey MacDermod and Jerry Guintivano and Lana Cleland and Miller, {Allison L} and Lauren Harper and Larsen, {Janne T} and Zeynep Yilmaz and Jakob Grove and Sullivan, {Patrick F} and Petersen, {Liselotte V} and Jennifer Jordan and Kennedy, {Martin A} and Martin, {Nicholas G}",
year = "2021",
month = may,
doi = "10.1186/s12888-021-03212-3",
language = "English",
volume = "21",
journal = "B M C Psychiatry",
issn = "1471-244X",
publisher = "BioMed Central Ltd.",

}

RIS

TY - JOUR

T1 - The Eating Disorders Genetics Initiative (EDGI)

T2 - study protocol

AU - Bulik, Cynthia M

AU - Thornton, Laura M

AU - Parker, Richard

AU - Kennedy, Hannah

AU - Baker, Jessica H

AU - MacDermod, Casey

AU - Guintivano, Jerry

AU - Cleland, Lana

AU - Miller, Allison L

AU - Harper, Lauren

AU - Larsen, Janne T

AU - Yilmaz, Zeynep

AU - Grove, Jakob

AU - Sullivan, Patrick F

AU - Petersen, Liselotte V

AU - Jordan, Jennifer

AU - Kennedy, Martin A

AU - Martin, Nicholas G

PY - 2021/5

Y1 - 2021/5

N2 - BACKGROUND: The Eating Disorders Genetics Initiative (EDGI) is an international investigation exploring the role of genes and environment in anorexia nervosa, bulimia nervosa, and binge-eating disorder.METHODS: A total of 14,500 individuals with eating disorders and 1500 controls will be included from the United States (US), Australia (AU), New Zealand (NZ), and Denmark (DK). In the US, AU, and NZ, participants will complete comprehensive online phenotyping and will submit a saliva sample for genotyping. In DK, individuals with eating disorders will be identified by the National Patient Register, and genotyping will occur using bloodspots archived from birth. A genome-wide association study will be conducted within EDGI and via meta-analysis with other data from the Eating Disorders Working Group of the Psychiatric Genomics Consortium (PGC-ED).DISCUSSION: EDGI represents the largest genetic study of eating disorders ever to be conducted and is designed to rapidly advance the study of the genetics of the three major eating disorders (anorexia nervosa, bulimia nervosa, and binge-eating disorder). We will explicate the genetic architecture of eating disorders relative to each other and to other psychiatric and metabolic disorders and traits. Our goal is for EDGI to deliver "actionable" findings that can be transformed into clinically meaningful insights.TRIAL REGISTRATION: EDGI is a registered clinical trial: clinicaltrials.gov NCT04378101 .

AB - BACKGROUND: The Eating Disorders Genetics Initiative (EDGI) is an international investigation exploring the role of genes and environment in anorexia nervosa, bulimia nervosa, and binge-eating disorder.METHODS: A total of 14,500 individuals with eating disorders and 1500 controls will be included from the United States (US), Australia (AU), New Zealand (NZ), and Denmark (DK). In the US, AU, and NZ, participants will complete comprehensive online phenotyping and will submit a saliva sample for genotyping. In DK, individuals with eating disorders will be identified by the National Patient Register, and genotyping will occur using bloodspots archived from birth. A genome-wide association study will be conducted within EDGI and via meta-analysis with other data from the Eating Disorders Working Group of the Psychiatric Genomics Consortium (PGC-ED).DISCUSSION: EDGI represents the largest genetic study of eating disorders ever to be conducted and is designed to rapidly advance the study of the genetics of the three major eating disorders (anorexia nervosa, bulimia nervosa, and binge-eating disorder). We will explicate the genetic architecture of eating disorders relative to each other and to other psychiatric and metabolic disorders and traits. Our goal is for EDGI to deliver "actionable" findings that can be transformed into clinically meaningful insights.TRIAL REGISTRATION: EDGI is a registered clinical trial: clinicaltrials.gov NCT04378101 .

KW - Australia

KW - Bulimia Nervosa/genetics

KW - Feeding and Eating Disorders/genetics

KW - Genome-Wide Association Study

KW - Humans

KW - Meta-Analysis as Topic

KW - New Zealand

KW - United States

U2 - 10.1186/s12888-021-03212-3

DO - 10.1186/s12888-021-03212-3

M3 - Journal article

C2 - 33947359

VL - 21

JO - B M C Psychiatry

JF - B M C Psychiatry

SN - 1471-244X

M1 - 234

ER -