Department of Psychology and Behavioural Sciences

The early adolescent brain on music: Analysis of functional dynamics reveals engagement of orbitofrontal cortex reward system

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DOI

Music listening plays a pivotal role for children and adolescents, yet it remains unclear how music modulates brain activity at the level of functional networks in this young population. Analysing the dynamics of brain networks occurring and dissolving over time in response to music can provide a better understanding of the neural underpinning of music listening. We collected functional magnetic resonance imaging (fMRI) data from 17 preadolescents aged 10–11 years while listening to two similar music pieces separated by periods without music. We subsequently tracked the occurrence of functional brain networks over the recording time using a recent method that detects recurrent patterns of phase-locking in the fMRI signals: the leading eigenvector dynamics analysis (LEiDA). The probabilities of occurrence and switching profiles of different functional networks were compared between periods of music and no music. Our results showed significantly increased occurrence of a specific functional network during the two music pieces compared to no music, involving the medial orbitofrontal and ventromedial prefrontal cortices—a brain subsystem associated to reward processing. Moreover, the higher the musical reward sensitivity of the preadolescents, the more this network was preceded by a pattern involving the insula. Our findings highlight the involvement of a brain subsystem associated with hedonic and emotional processing during music listening in the early adolescent brain. These results offer novel insight into the neural underpinnings of musical reward in early adolescence, improving our understanding of the important role and the potential benefits of music at this delicate age.

Original languageEnglish
JournalHuman Brain Mapping
Volume1
Issue18
Number of pages18
ISSN1065-9471
DOIs
Publication statusE-pub ahead of print - 7 Sep 2022

Bibliographical note

Funding Information:
This work was supported by the Center for Music in the Brain (MIB), funded by the Danish National Research Foundation (DNRF 117). Morten L. Kringelbach is supported by the ERC Consolidator Grant: CAREGIVING (n. 615539), MIB (DNRF 117), and Centre for Eudaimonia and Human Flourishing funded by the Pettit and Carlsberg Foundations. Joana Cabral received funding from the Portuguese Foundation for Science and Technology (FCT), projects UIDB/50026/2020, UIDP/50026/2020, and CEECIND/03325/2017.

Funding Information:
Danmarks Grundforskningsfond, Grant/Award Number: DNRF117; ERC Consolidator Grant, Grant/Award Number: CAREGIVING 615539; Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Grant/Award Number: UIDB/50026/2020 Funding information

Publisher Copyright:
© 2022 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.

    Research areas

  • adolescence, dynamic functional connectivity, music listening, orbitofrontal cortex, pleasure

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