The dynamics of human cognition: Increasing global integration coupled with decreasing segregation found using iEEG

Josephine Cruzat*, Gustavo Deco, Adrià Tauste-Campo, Alessandro Principe, Albert Costa, Morten L. Kringelbach, Rodrigo Rocamora

*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Abstract

Cognitive processing requires the ability to flexibly integrate and process information across large brain networks. How do brain networks dynamically reorganize to allow broad communication between many different brain regions in order to integrate information? We record neural activity from 12 epileptic patients using intracranial EEG while performing three cognitive tasks. We assess how the functional connectivity between different brain areas changes to facilitate communication across them. At the topological level, this facilitation is characterized by measures of integration and segregation. Across all patients, we found significant increases in integration and decreases in segregation during cognitive processing, especially in the gamma band (50–90 Hz). We also found higher levels of global synchronization and functional connectivity during task execution, again particularly in the gamma band. More importantly, functional connectivity modulations were not caused by changes in the level of the underlying oscillations. Instead, these modulations were caused by a rearrangement of the mutual synchronization between the different nodes as proposed by the “Communication Through Coherence” Theory.

Original languageEnglish
JournalNeuroImage
Volume172
Pages (from-to)492-505
Number of pages14
ISSN1053-8119
DOIs
Publication statusPublished - 15 May 2018

Keywords

  • Cognition
  • CTC theory
  • iEEG
  • Integration
  • Segregation

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