The Crystal Structure of Human α(2) -Macroglobulin Reveals a Unique Molecular Cage

Aniebrys Marrero, Stephane Duquerroy, Stefano Trapani, Theodoros Goulas, Tibisay Guevara, Gregers Rom Andersen, Jorge Navaza, Lars Sottrup-Jensen, F Xavier Gomis-Rüth

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Abstract

I'm your Venus: The crystal structure of the human methylamine-induced form of α(2) -macroglobulin (α(2) M) shows its large central cavity can accommodate two medium-sized proteinases (see structure, front part clipped off to better show central cavity). Twelve major entrances provide access for small substrates to the cavity and the still-active trapped "prey". The structure unveils the molecular basis of the unique "venus flytrap" mechanism of α(2) M.
Original languageEnglish
JournalAngewandte Chemie International Edition
Volume51
Issue14
Pages (from-to)3340-44
ISSN1433-7851
DOIs
Publication statusPublished - 2012

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