The coverage of influenza vaccination and predictors of influenza non-vaccination in Danish cancer patients: A nationwide register-based cohort study

Lau Amdisen, Lars Pedersen, Niels Abildgaard, Christine Stabell Benn, Mikael Rørth, Deirdre Cronin-Fenton, Signe Sørup

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Abstract

Background: Influenza vaccination is recommended and provided free-of-charge to Danish citizens aged ≥65 years and to individuals with acquired immunodeficiency. We aimed to estimate influenza vaccination coverage and investigate predictors of influenza non-vaccination in Danish cancer patients. Methods: A nationwide cohort study of all Danish citizens aged ≥18 years with an incident cancer diagnosis between 2002 and 2017. Using national registries, we assessed information on influenza vaccination and potential predictors of influenza non-vaccination. We estimated adjusted prevalence ratios (aPR) of influenza non-vaccination for patients aged <65 years and ≥65 years. Results: We observed 269,863 patients during 840,876 influenza vaccination seasons. The influenza vaccination coverage was 14 % for cancer patients <65 years and 51 % for those ≥65 years. No influenza vaccination in the previous season was associated with non-vaccination in the current season (<65 years: aPR = 2.75, 95 %CI = 2.71–2.80; ≥65 years: aPR = 5.15, 95 %CI = 5.10–5.21). Haematological cancer patients receiving chemotherapy had lower vaccination prevalence compared with those not receiving chemotherapy. Conclusions: The influenza vaccination coverage was low among cancer patients. Influenza non-vaccination in the previous season was the strongest predictor of not receiving influenza vaccination in the current season. Haematological cancer patients on current chemotherapy had lower vaccination prevalence than those not currently receiving chemotherapy.

Original languageEnglish
JournalVaccine
Volume42
Issue7
Pages (from-to)1690-1697
Number of pages8
ISSN0264-410X
DOIs
Publication statusPublished - Mar 2024

Keywords

  • Chemotherapy
  • Haematological cancer
  • Immunisation
  • Immunosuppression
  • Influenza vaccination
  • Seasonal influenza
  • Solid tumours
  • Influenza Vaccines/therapeutic use
  • Hematologic Neoplasms
  • Humans
  • Influenza, Human/epidemiology
  • Vaccination
  • Denmark/epidemiology
  • Adolescent
  • Adult
  • Seasons
  • Neoplasms/epidemiology
  • Cohort Studies

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