The bonobo genome compared with the chimpanzee and human genomes

Kay Prüfer; Kasper Munch; Ines Hellmann; Keiko Akagi; Jason R Miller; Brian Walenz; Sergey Koren; Granger Sutton; Chinnappa Kodira; Roger Winer; James R Knight; James C Mullikin; Stephen J Meader; Chris P Ponting; Gerton Lunter; Saneyuki Higashino; Asger Hobolth; Julien Dutheil; Emre Karakoç; Can Alkan; Saba Sajjadian; Claudia Rita Catacchio; Mario Ventura; Tomas Marques-Bonet; Evan E Eichler; Claudine André; Rebeca Atencia; Lawrence Mugisha; Jörg Junhold; Nick Patterson; Michael Siebauer; Jeffrey M Good; Anne Fischer; Susan E Ptak; Michael Lachmann; David E Symer; Thomas Mailund; Mikkel H Schierup; Aida M Andrés; Janet Kelso; Svante Pääbo

doi:10.1038/nature11128

The bonobo genome compared with the chimpanzee and human genomes

Kay Prüfer, Kasper Munch, Ines Hellmann, Keiko Akagi, Jason R Miller, Brian Walenz, Sergey Koren, Granger Sutton, Chinnappa Kodira, Roger Winer, James R Knight, James C Mullikin, Stephen J Meader, Chris P Ponting, Gerton Lunter, Saneyuki Higashino, Asger Hobolth, Julien Dutheil, Emre Karakoç, Can AlkanSaba Sajjadian, Claudia Rita Catacchio, Mario Ventura, Tomas Marques-Bonet, Evan E Eichler, Claudine André, Rebeca Atencia, Lawrence Mugisha, Jörg Junhold, Nick Patterson, Michael Siebauer, Jeffrey M Good, Anne Fischer, Susan E Ptak, Michael Lachmann, David E Symer, Thomas Mailund, Mikkel H Schierup, Aida M Andrés, Janet Kelso, Svante Pääbo

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Abstract

Two African apes are the closest living relatives of humans: the chimpanzee (Pan troglodytes) and the bonobo (Pan paniscus). Although they are similar in many respects, bonobos and chimpanzees differ strikingly in key social and sexual behaviours, and for some of these traits they show more similarity with humans than with each other. Here we report the sequencing and assembly of the bonobo genome to study its evolutionary relationship with the chimpanzee and human genomes. We find that more than three per cent of the human genome is more closely related to either the bonobo or the chimpanzee genome than these are to each other. These regions allow various aspects of the ancestry of the two ape species to be reconstructed. In addition, many of the regions that overlap genes may eventually help us understand the genetic basis of phenotypes that humans share with one of the two apes to the exclusion of the other.

Original language	English
Journal	Nature
Volume	486
Issue	7404
Pages (from-to)	527-31
Number of pages	5
ISSN	0028-0836
DOIs	https://doi.org/10.1038/nature11128
Publication status	Published - 2012

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Prüfer, K., Munch, K., Hellmann, I., Akagi, K., Miller, J. R., Walenz, B., Koren, S., Sutton, G., Kodira, C., Winer, R., Knight, J. R., Mullikin, J. C., Meader, S. J., Ponting, C. P., Lunter, G., Higashino, S., Hobolth, A., Dutheil, J., Karakoç, E., ... Pääbo, S. (2012). The bonobo genome compared with the chimpanzee and human genomes. Nature, 486(7404), 527-31. https://doi.org/10.1038/nature11128

@article{e44238a4af5949ccb75418ed16b96200,

title = "The bonobo genome compared with the chimpanzee and human genomes",

abstract = "Two African apes are the closest living relatives of humans: the chimpanzee (Pan troglodytes) and the bonobo (Pan paniscus). Although they are similar in many respects, bonobos and chimpanzees differ strikingly in key social and sexual behaviours, and for some of these traits they show more similarity with humans than with each other. Here we report the sequencing and assembly of the bonobo genome to study its evolutionary relationship with the chimpanzee and human genomes. We find that more than three per cent of the human genome is more closely related to either the bonobo or the chimpanzee genome than these are to each other. These regions allow various aspects of the ancestry of the two ape species to be reconstructed. In addition, many of the regions that overlap genes may eventually help us understand the genetic basis of phenotypes that humans share with one of the two apes to the exclusion of the other.",

author = "Kay Pr{\"u}fer and Kasper Munch and Ines Hellmann and Keiko Akagi and Miller, {Jason R} and Brian Walenz and Sergey Koren and Granger Sutton and Chinnappa Kodira and Roger Winer and Knight, {James R} and Mullikin, {James C} and Meader, {Stephen J} and Ponting, {Chris P} and Gerton Lunter and Saneyuki Higashino and Asger Hobolth and Julien Dutheil and Emre Karako{\c c} and Can Alkan and Saba Sajjadian and Catacchio, {Claudia Rita} and Mario Ventura and Tomas Marques-Bonet and Eichler, {Evan E} and Claudine Andr{\'e} and Rebeca Atencia and Lawrence Mugisha and J{\"o}rg Junhold and Nick Patterson and Michael Siebauer and Good, {Jeffrey M} and Anne Fischer and Ptak, {Susan E} and Michael Lachmann and Symer, {David E} and Thomas Mailund and Schierup, {Mikkel H} and Andr{\'e}s, {Aida M} and Janet Kelso and Svante P{\"a}{\"a}bo",

year = "2012",

doi = "10.1038/nature11128",

language = "English",

volume = "486",

pages = "527--31",

journal = "Nature",

issn = "0028-0836",

publisher = "Nature Publishing Group",

number = "7404",

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Prüfer, K, Munch, K, Hellmann, I, Akagi, K, Miller, JR, Walenz, B, Koren, S, Sutton, G, Kodira, C, Winer, R, Knight, JR, Mullikin, JC, Meader, SJ, Ponting, CP, Lunter, G, Higashino, S, Hobolth, A, Dutheil, J, Karakoç, E, Alkan, C, Sajjadian, S, Catacchio, CR, Ventura, M, Marques-Bonet, T, Eichler, EE, André, C, Atencia, R, Mugisha, L, Junhold, J, Patterson, N, Siebauer, M, Good, JM, Fischer, A, Ptak, SE, Lachmann, M, Symer, DE, Mailund, T, Schierup, MH, Andrés, AM, Kelso, J & Pääbo, S 2012, 'The bonobo genome compared with the chimpanzee and human genomes', Nature, vol. 486, no. 7404, pp. 527-31. https://doi.org/10.1038/nature11128

TY - JOUR

T1 - The bonobo genome compared with the chimpanzee and human genomes

AU - Prüfer, Kay

AU - Munch, Kasper

AU - Hellmann, Ines

AU - Akagi, Keiko

AU - Miller, Jason R

AU - Walenz, Brian

AU - Koren, Sergey

AU - Sutton, Granger

AU - Kodira, Chinnappa

AU - Winer, Roger

AU - Knight, James R

AU - Mullikin, James C

AU - Meader, Stephen J

AU - Ponting, Chris P

AU - Lunter, Gerton

AU - Higashino, Saneyuki

AU - Hobolth, Asger

AU - Dutheil, Julien

AU - Karakoç, Emre

AU - Alkan, Can

AU - Sajjadian, Saba

AU - Catacchio, Claudia Rita

AU - Ventura, Mario

AU - Marques-Bonet, Tomas

AU - Eichler, Evan E

AU - André, Claudine

AU - Atencia, Rebeca

AU - Mugisha, Lawrence

AU - Junhold, Jörg

AU - Patterson, Nick

AU - Siebauer, Michael

AU - Good, Jeffrey M

AU - Fischer, Anne

AU - Ptak, Susan E

AU - Lachmann, Michael

AU - Symer, David E

AU - Mailund, Thomas

AU - Schierup, Mikkel H

AU - Andrés, Aida M

AU - Kelso, Janet

AU - Pääbo, Svante

PY - 2012

Y1 - 2012

N2 - Two African apes are the closest living relatives of humans: the chimpanzee (Pan troglodytes) and the bonobo (Pan paniscus). Although they are similar in many respects, bonobos and chimpanzees differ strikingly in key social and sexual behaviours, and for some of these traits they show more similarity with humans than with each other. Here we report the sequencing and assembly of the bonobo genome to study its evolutionary relationship with the chimpanzee and human genomes. We find that more than three per cent of the human genome is more closely related to either the bonobo or the chimpanzee genome than these are to each other. These regions allow various aspects of the ancestry of the two ape species to be reconstructed. In addition, many of the regions that overlap genes may eventually help us understand the genetic basis of phenotypes that humans share with one of the two apes to the exclusion of the other.

AB - Two African apes are the closest living relatives of humans: the chimpanzee (Pan troglodytes) and the bonobo (Pan paniscus). Although they are similar in many respects, bonobos and chimpanzees differ strikingly in key social and sexual behaviours, and for some of these traits they show more similarity with humans than with each other. Here we report the sequencing and assembly of the bonobo genome to study its evolutionary relationship with the chimpanzee and human genomes. We find that more than three per cent of the human genome is more closely related to either the bonobo or the chimpanzee genome than these are to each other. These regions allow various aspects of the ancestry of the two ape species to be reconstructed. In addition, many of the regions that overlap genes may eventually help us understand the genetic basis of phenotypes that humans share with one of the two apes to the exclusion of the other.

U2 - 10.1038/nature11128

DO - 10.1038/nature11128

M3 - Journal article

C2 - 22722832

SN - 0028-0836

VL - 486

SP - 527

EP - 531

JO - Nature

JF - Nature

IS - 7404

ER -

The bonobo genome compared with the chimpanzee and human genomes

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