The antidepressant-like effect of galanin in the dorsal raphe nucleus of rats involves GAL receptors

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  • Mayara Machado de Souza, Department of Pharmaceutical Sciences, Health Science Centre, Federal University of Espirito Santo, Vitoria, ES, 29043-900, Brazil.
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  • Gabriela Pandini Silote, Department of Physics and Chemistry, School of Pharmaceutical Sciences, University of São Paulo, Ribeirão Preto, SP, Brazil; Biochemistry and Pharmacology Postgraduate Program, Health Science Center, Federal University of Espirito Santo, Vitoria, ES, 29043-900, Brazil.
  • ,
  • Leticia Santos Herbst, Department of Pharmaceutical Sciences, Health Science Centre, Federal University of Espirito Santo, Vitoria, ES, 29043-900, Brazil.
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  • Vinicius Rafael Funck, Biochemistry and Pharmacology Postgraduate Program, Health Science Center, Federal University of Espirito Santo, Vitoria, ES, 29043-900, Brazil.
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  • Samia Regiane Lourenço Joca
  • Vanessa Beijamini, Department of Pharmaceutical Sciences, Health Science Centre, Federal University of Espirito Santo, Vitoria, ES, 29043-900, Brazil. Electronic address: vanessa.harres@ufes.br.

Galanin is a neuropeptide distributed in human and rat brain regions that are involved with emotional regulation, such as the dorsal raphe nucleus (DRN). Galanin effects in the DRN are mediated by GAL1 and GAL2 receptors. Intracerebral infusion of a GAL2 (AR-M1896) or a GAL1 (M617) agonist induced either antidepressant or depressive-like effect, respectively, in rats exposed to the forced swimming test (FST). However, it is not clear if GAL1 and/or GAL2 receptors present in the DRN would be involved in such effects. Therefore, we investigated the effects induced by intra-DRN infusion of galanin (0.3 nmol), AR-M1896 (1 nmol, GAL2 agonist), or M617 (GAL1 agonist) in rats exposed to the FST. Galanin and AR-M1896 intra-DRN administration induced antidepressant-like effect in the FST. However, M617 did not induce any change in the FST. Neither M617 nor AR-M1896 changed the locomotor activity of rats in the open field test. Intra-DRN pre-treatment with M871 (1 nmol), a selective GAL2 antagonist, counteracted the antidepressant-like effect induced by galanin. These results suggest that galanin signaling through GAL2 receptors in the DRN produces triggers antidepressant-like effect.

Original languageEnglish
JournalNeuroscience Letters
Volume681
Pages (from-to)26-30
Number of pages5
ISSN0304-3940
DOIs
Publication statusPublished - 2018

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