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The agotrons: Gene regulators or Argonaute protectors?

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The agotrons: Gene regulators or Argonaute protectors? / Stagsted, Lotte V W; Daugaard, Iben; Hansen, Thomas B.

In: BioEssays, Vol. 39, No. 4, 07.03.2017.

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@article{944ba0477401428097139c1505389fae,
title = "The agotrons: Gene regulators or Argonaute protectors?",
abstract = "Over the last decades, it has become evident that highly complex networks of regulators govern post-transcriptional regulation of gene expression. A novel class of Argonaute (Ago)-associated RNA molecules, the agotrons, was recently shown to function in a Drosha- and Dicer-independent manner, hence bypassing the maturation steps required for canonical microRNA (miRNA) biogenesis. Agotrons are found in most mammals and associate with Ago as ∼100 nucleotide (nt) long RNA species. Here, we speculate on the functional and biological relevance of agotrons: (i) agotrons could serve as non-promiscuous miRNA-like regulators with reduced off-targeting or (ii) agotrons could encompass other putative functions, such as protecting Ago proteins from taking up aberrant short RNAs or by rescuing and stabilizing otherwise unloaded Ago-proteins from degradation. Collectively, agotrons have emerged as a novel class of interesting non-coding RNA molecules, but their full functional potential and biological impact still remain to be disclosed.",
keywords = "Journal Article, Review",
author = "Stagsted, {Lotte V W} and Iben Daugaard and Hansen, {Thomas B}",
note = "{\circledC} 2017 WILEY Periodicals, Inc.",
year = "2017",
month = "3",
day = "7",
doi = "10.1002/bies.201600239",
language = "English",
volume = "39",
journal = "BioEssays",
issn = "0265-9247",
publisher = "John/Wiley & Sons Ltd.",
number = "4",

}

RIS

TY - JOUR

T1 - The agotrons: Gene regulators or Argonaute protectors?

AU - Stagsted, Lotte V W

AU - Daugaard, Iben

AU - Hansen, Thomas B

N1 - © 2017 WILEY Periodicals, Inc.

PY - 2017/3/7

Y1 - 2017/3/7

N2 - Over the last decades, it has become evident that highly complex networks of regulators govern post-transcriptional regulation of gene expression. A novel class of Argonaute (Ago)-associated RNA molecules, the agotrons, was recently shown to function in a Drosha- and Dicer-independent manner, hence bypassing the maturation steps required for canonical microRNA (miRNA) biogenesis. Agotrons are found in most mammals and associate with Ago as ∼100 nucleotide (nt) long RNA species. Here, we speculate on the functional and biological relevance of agotrons: (i) agotrons could serve as non-promiscuous miRNA-like regulators with reduced off-targeting or (ii) agotrons could encompass other putative functions, such as protecting Ago proteins from taking up aberrant short RNAs or by rescuing and stabilizing otherwise unloaded Ago-proteins from degradation. Collectively, agotrons have emerged as a novel class of interesting non-coding RNA molecules, but their full functional potential and biological impact still remain to be disclosed.

AB - Over the last decades, it has become evident that highly complex networks of regulators govern post-transcriptional regulation of gene expression. A novel class of Argonaute (Ago)-associated RNA molecules, the agotrons, was recently shown to function in a Drosha- and Dicer-independent manner, hence bypassing the maturation steps required for canonical microRNA (miRNA) biogenesis. Agotrons are found in most mammals and associate with Ago as ∼100 nucleotide (nt) long RNA species. Here, we speculate on the functional and biological relevance of agotrons: (i) agotrons could serve as non-promiscuous miRNA-like regulators with reduced off-targeting or (ii) agotrons could encompass other putative functions, such as protecting Ago proteins from taking up aberrant short RNAs or by rescuing and stabilizing otherwise unloaded Ago-proteins from degradation. Collectively, agotrons have emerged as a novel class of interesting non-coding RNA molecules, but their full functional potential and biological impact still remain to be disclosed.

KW - Journal Article

KW - Review

U2 - 10.1002/bies.201600239

DO - 10.1002/bies.201600239

M3 - Journal article

C2 - 28266707

VL - 39

JO - BioEssays

JF - BioEssays

SN - 0265-9247

IS - 4

ER -