The ADDITION study: proposed trial of the cost-effectiveness of an intensive multifactorial intervention on morbidity and mortality among people with Type 2 diabetes detected by screening

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  • Torsten Lauritzen
  • S Griffin
  • ,
  • K Borch-Johnsen
  • ,
  • N J Wareham
  • ,
  • B H Wolffenbuttel
  • ,
  • G Rutten
  • ,
  • Anglo-Danish-Dutch Study of Intensive Treatment in People with Screen Detected Diabetes in Primary Care
  • Institute of General Medical Practice
OBJECTIVE: The overall aims of the ADDITION study are to evaluate whether screening for prevalent undiagnosed Type 2 diabetes is feasible, and whether subsequent optimised intensive treatment of diabetes, and associated risk factors, is feasible and beneficial. DESIGN: Population-based screening in three European countries followed by an open, randomised controlled trial. SUBJECTS AND METHODS: People aged 40-69 y in the community, without known diabetes, will be offered a random capillary blood glucose screening test by their primary care physicians, followed, if equal to or greater than 5.5 mmol/l, by fasting and 2-h post-glucose-challenge blood glucose measurements. Three thousand newly diagnosed patients will subsequently receive conventional treatment (according to current national guidelines) or intensive multifactorial treatment (lifestyle advice, prescription of aspirin and ACE-inhibitors, in addition to protocol-driven tight control of blood glucose, blood pressure and cholesterol). Patients allocated to intensive treatment will be further randomised to centre-specific interventions to motivate adherence to lifestyle changes and medication. Duration of follow-up is planned for 5 y. Endpoints will include mortality, macrovascular and microvascular complications, patient health status and satisfaction, process-of-care indicators and costs.
Original languageEnglish
JournalInternational Journal of Obesity
Volume24
IssueSuppl 3
Pages (from-to)S6-11
ISSN0307-0565
Publication statusPublished - 1 Sep 2000

    Research areas

  • Adult, Aged, Blood Glucose, Cost-Benefit Analysis, Denmark, Diabetes Mellitus, Type 2, England, Female, Humans, Hyperglycemia, Intervention Studies, Male, Mass Screening, Middle Aged, Multicenter Studies as Topic, Netherlands, Practice Guidelines as Topic, Prevalence, Primary Health Care, Randomized Controlled Trials as Topic, Risk Factors, Vascular Diseases

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