The acute effects of milk intake on calcium homeostasis and cardiovascular outcome: A randomized crossover trial in postmenopausal women

Rasmus Espersen; Lars Rejnmark

doi:10.1111/cen.14632

The acute effects of milk intake on calcium homeostasis and cardiovascular outcome: A randomized crossover trial in postmenopausal women

^*Corresponding author for this work

Department of Clinical Medicine - Department of Endocrinology and Internal Medicine

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

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Abstract

Objective: The importance of calcium intake from dairy in regard to cardiovascular health has been investigated in several studies with discrepant results. Hence, we aim to investigate the immediate effects of milk intake on cardiovascular function. Design: A randomized crossover study with at least 10 days for washout between the two interventions, 500 ml of water with 200 µg of cholecalciferol or 500 ml of semi-skimmed milk containing approximately 600 mg of calcium with 200 µg of cholecalciferol. Patients: Twenty community-based postmenopausal women aged 60–80 years. Measurements: Parathyroid hormone and ionized calcium were measured at baseline and after 2 and 4 h on each study day. Pulse wave analysis and velocity were measured at baseline and after 4 h on each study day. Results: Compared to water, milk intake increased ionized calcium levels by 0.02 mmol/L (p =.029) and decreased parathyroid hormone levels by 1.78 pmol/L (p <.001). The two interventions caused no changes as measured 4 h after the intervention in the following indices of cardiovascular health; pulse wave velocity, brachial diastolic or systolic blood pressure, central diastolic or systolic blood pressure, mean arterial pressure, pulse pressure, augmentation pressure, augmentation index, heart rate or pulse transit time. Conclusions: Despite significant changes in calcium homeostasis with increased levels of ionized calcium following milk intake, no acute effects seem to occur on measures of cardiovascular health.

Original language	English
Journal	Clinical Endocrinology
Volume	96
Issue	6
Pages (from-to)	812-818
Number of pages	7
ISSN	0300-0664
DOIs	https://doi.org/10.1111/cen.14632
Publication status	Published - Jun 2022

Keywords

blood pressure
calcium
cross-over studies
milk
parathyroid hormone
pulse wave analysis
vascular stiffness
MORTALITY
METAANALYSIS
RISK
BLOOD-PRESSURE
PREDICTION
SERUM-CALCIUM
STIFFNESS
CITRATE
DISEASE
CONSUMPTION
Water/pharmacology
Pulse Wave Analysis
Humans
Homeostasis
Parathyroid Hormone
Vascular Stiffness/physiology
Bone Density Conservation Agents
Postmenopause
Female
Milk
Blood Pressure/physiology
Cholecalciferol
Calcium/pharmacology
Cross-Over Studies
Animals

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10.1111/cen.14632Licence: CC BY-NC-ND

Clinical Endocrinology - 2021 - Espersen - The acute effects of milk intake on calcium homeostasis and cardiovascularFinal published version, 541 KBLicence: CC BY-NC-ND

Cite this

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title = "The acute effects of milk intake on calcium homeostasis and cardiovascular outcome: A randomized crossover trial in postmenopausal women",

abstract = "Objective: The importance of calcium intake from dairy in regard to cardiovascular health has been investigated in several studies with discrepant results. Hence, we aim to investigate the immediate effects of milk intake on cardiovascular function. Design: A randomized crossover study with at least 10 days for washout between the two interventions, 500 ml of water with 200 µg of cholecalciferol or 500 ml of semi-skimmed milk containing approximately 600 mg of calcium with 200 µg of cholecalciferol. Patients: Twenty community-based postmenopausal women aged 60–80 years. Measurements: Parathyroid hormone and ionized calcium were measured at baseline and after 2 and 4 h on each study day. Pulse wave analysis and velocity were measured at baseline and after 4 h on each study day. Results: Compared to water, milk intake increased ionized calcium levels by 0.02 mmol/L (p =.029) and decreased parathyroid hormone levels by 1.78 pmol/L (p <.001). The two interventions caused no changes as measured 4 h after the intervention in the following indices of cardiovascular health; pulse wave velocity, brachial diastolic or systolic blood pressure, central diastolic or systolic blood pressure, mean arterial pressure, pulse pressure, augmentation pressure, augmentation index, heart rate or pulse transit time. Conclusions: Despite significant changes in calcium homeostasis with increased levels of ionized calcium following milk intake, no acute effects seem to occur on measures of cardiovascular health.",

keywords = "blood pressure, calcium, cross-over studies, milk, parathyroid hormone, pulse wave analysis, vascular stiffness, MORTALITY, METAANALYSIS, RISK, BLOOD-PRESSURE, PREDICTION, SERUM-CALCIUM, STIFFNESS, CITRATE, DISEASE, CONSUMPTION, Water/pharmacology, Pulse Wave Analysis, Humans, Homeostasis, Parathyroid Hormone, Vascular Stiffness/physiology, Bone Density Conservation Agents, Postmenopause, Female, Milk, Blood Pressure/physiology, Cholecalciferol, Calcium/pharmacology, Cross-Over Studies, Animals",

author = "Rasmus Espersen and Lars Rejnmark",

note = "{\textcopyright} 2021 The Authors. Clinical Endocrinology published by John Wiley & Sons Ltd.",

year = "2022",

month = jun,

doi = "10.1111/cen.14632",

language = "English",

volume = "96",

pages = "812--818",

journal = "Clinical Endocrinology",

issn = "0300-0664",

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The acute effects of milk intake on calcium homeostasis and cardiovascular outcome: A randomized crossover trial in postmenopausal women. / Espersen, Rasmus ; Rejnmark, Lars.
In: Clinical Endocrinology, Vol. 96, No. 6, 06.2022, p. 812-818.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

TY - JOUR

T1 - The acute effects of milk intake on calcium homeostasis and cardiovascular outcome

T2 - A randomized crossover trial in postmenopausal women

AU - Espersen, Rasmus

AU - Rejnmark, Lars

PY - 2022/6

Y1 - 2022/6

N2 - Objective: The importance of calcium intake from dairy in regard to cardiovascular health has been investigated in several studies with discrepant results. Hence, we aim to investigate the immediate effects of milk intake on cardiovascular function. Design: A randomized crossover study with at least 10 days for washout between the two interventions, 500 ml of water with 200 µg of cholecalciferol or 500 ml of semi-skimmed milk containing approximately 600 mg of calcium with 200 µg of cholecalciferol. Patients: Twenty community-based postmenopausal women aged 60–80 years. Measurements: Parathyroid hormone and ionized calcium were measured at baseline and after 2 and 4 h on each study day. Pulse wave analysis and velocity were measured at baseline and after 4 h on each study day. Results: Compared to water, milk intake increased ionized calcium levels by 0.02 mmol/L (p =.029) and decreased parathyroid hormone levels by 1.78 pmol/L (p <.001). The two interventions caused no changes as measured 4 h after the intervention in the following indices of cardiovascular health; pulse wave velocity, brachial diastolic or systolic blood pressure, central diastolic or systolic blood pressure, mean arterial pressure, pulse pressure, augmentation pressure, augmentation index, heart rate or pulse transit time. Conclusions: Despite significant changes in calcium homeostasis with increased levels of ionized calcium following milk intake, no acute effects seem to occur on measures of cardiovascular health.

AB - Objective: The importance of calcium intake from dairy in regard to cardiovascular health has been investigated in several studies with discrepant results. Hence, we aim to investigate the immediate effects of milk intake on cardiovascular function. Design: A randomized crossover study with at least 10 days for washout between the two interventions, 500 ml of water with 200 µg of cholecalciferol or 500 ml of semi-skimmed milk containing approximately 600 mg of calcium with 200 µg of cholecalciferol. Patients: Twenty community-based postmenopausal women aged 60–80 years. Measurements: Parathyroid hormone and ionized calcium were measured at baseline and after 2 and 4 h on each study day. Pulse wave analysis and velocity were measured at baseline and after 4 h on each study day. Results: Compared to water, milk intake increased ionized calcium levels by 0.02 mmol/L (p =.029) and decreased parathyroid hormone levels by 1.78 pmol/L (p <.001). The two interventions caused no changes as measured 4 h after the intervention in the following indices of cardiovascular health; pulse wave velocity, brachial diastolic or systolic blood pressure, central diastolic or systolic blood pressure, mean arterial pressure, pulse pressure, augmentation pressure, augmentation index, heart rate or pulse transit time. Conclusions: Despite significant changes in calcium homeostasis with increased levels of ionized calcium following milk intake, no acute effects seem to occur on measures of cardiovascular health.

KW - blood pressure

KW - calcium

KW - cross-over studies

KW - milk

KW - parathyroid hormone

KW - pulse wave analysis

KW - vascular stiffness

KW - MORTALITY

KW - METAANALYSIS

KW - RISK

KW - BLOOD-PRESSURE

KW - PREDICTION

KW - SERUM-CALCIUM

KW - STIFFNESS

KW - CITRATE

KW - DISEASE

KW - CONSUMPTION

KW - Water/pharmacology

KW - Pulse Wave Analysis

KW - Humans

KW - Homeostasis

KW - Parathyroid Hormone

KW - Vascular Stiffness/physiology

KW - Bone Density Conservation Agents

KW - Postmenopause

KW - Female

KW - Milk

KW - Blood Pressure/physiology

KW - Cholecalciferol

KW - Calcium/pharmacology

KW - Cross-Over Studies

KW - Animals

U2 - 10.1111/cen.14632

DO - 10.1111/cen.14632

M3 - Journal article

C2 - 34755389

SN - 0300-0664

VL - 96

SP - 812

EP - 818

JO - Clinical Endocrinology

JF - Clinical Endocrinology

IS - 6

ER -

The acute effects of milk intake on calcium homeostasis and cardiovascular outcome: A randomized crossover trial in postmenopausal women

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Keywords

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