Textures in magnetic resonance images of the ischemic rat brain treated with an anti-inflammatory agent

TY - JOUR

T1 - Textures in magnetic resonance images of the ischemic rat brain treated with an anti-inflammatory agent

AU - Chen, Gang

AU - Strzelecki, Michal

AU - Pang, Qi

AU - Kim, Hyongsuk

AU - Stødkilde-Jørgensen, Hans

N1 - Crown Copyright © 2010. Published by Elsevier Inc. All rights reserved.

PY - 2010

Y1 - 2010

N2 - Computer-based analysis of textures in magnetic resonance images provides a higher sensitivity to textural changes that cannot be recognized by the naked human eye. Thus, there is a better potential for identifying pathophysiological processes at an earlier stage or of a different character than even a trained radiologist can find. In the present study, the potential of texture analysis for in vivo identification of the administering effect of an anti-inflammatory drug in cerebral stroke in rats was evaluated. Twenty-seven Wistar rats underwent middle cerebral artery occlusion resulting in local ischemic brain infarct. One group of rats received alpha-melanocyte stimulating hormone (alpha-MSH) and a control group received saline only. T2-weighted images, apparent diffusion maps, and T2 maps were recorded by MR. Texture features were calculated in the T2-weighted images and correlated to the apparent diffusion coefficient (ADC) and the T2 values. From an array of tested texture features three independent features were tested further. Two of which were found to provide a significant discriminative classification between the control and the alpha-MSH groups. Furthermore, the same two texture features were significantly correlated to the ADCs. Thus, quantification of texture features can be helpful in detecting the effects of stroke therapy.

AB - Computer-based analysis of textures in magnetic resonance images provides a higher sensitivity to textural changes that cannot be recognized by the naked human eye. Thus, there is a better potential for identifying pathophysiological processes at an earlier stage or of a different character than even a trained radiologist can find. In the present study, the potential of texture analysis for in vivo identification of the administering effect of an anti-inflammatory drug in cerebral stroke in rats was evaluated. Twenty-seven Wistar rats underwent middle cerebral artery occlusion resulting in local ischemic brain infarct. One group of rats received alpha-melanocyte stimulating hormone (alpha-MSH) and a control group received saline only. T2-weighted images, apparent diffusion maps, and T2 maps were recorded by MR. Texture features were calculated in the T2-weighted images and correlated to the apparent diffusion coefficient (ADC) and the T2 values. From an array of tested texture features three independent features were tested further. Two of which were found to provide a significant discriminative classification between the control and the alpha-MSH groups. Furthermore, the same two texture features were significantly correlated to the ADCs. Thus, quantification of texture features can be helpful in detecting the effects of stroke therapy.

KW - MR

KW - MR

KW - ischemic rat brain

U2 - 10.1016/j.clinimag.2009.02.004

DO - 10.1016/j.clinimag.2009.02.004

M3 - Journal article

C2 - 20122513

SN - 0899-7071

VL - 34

SP - 7

EP - 13

JO - Clinical Imaging

JF - Clinical Imaging

IS - 1

ER -