Temporal trends of lipophilic persistent organic pollutants in serum from Danish nulliparous pregnant women 2011-2013

TY - JOUR

T1 - Temporal trends of lipophilic persistent organic pollutants in serum from Danish nulliparous pregnant women 2011-2013

AU - Olesen, Christian Bjerregaard

AU - Long, Manhai

AU - Ghisari, Mandana

AU - Bech, Bodil Hammer

AU - Nøhr, Ellen Aagaard

AU - Uldbjerg, Niels

AU - Henriksen, Tine Brink

AU - Olsen, Jørn

AU - Bonefeld-Jørgensen, Eva Cecilie

PY - 2017/7

Y1 - 2017/7

N2 - The use of the lipophilic persistent organic pollutants (POPs) including polychlorinated biphenyls (PCBs) and several organochlorine pesticides (OCPs) has been prohibited for more than 30 years. In this study, we present the temporal trends of the lipophilic POP serum concentrations in Danish nulliparous pregnant women between 2011 and 2013. We randomly selected 197 pregnant women (gestational age 11-13) from the Aarhus Birth Cohort. The concentrations of the lipophilic POPs in the serum samples were analyzed using gas chromatography. The concentrations were corrected for total serum lipids. The statistical analysis was performed by regression analysis with adjustment for age, BMI, gestational age at blood draw, and smoking status. The serum concentrations of PCB 118, 138, 153, 156, 170, 180, 187, and hexachlorobenzen, trans-nonachlor, β-hexachlorocyclohexane (β-HCH), and p,p'-dichlorodiphenyldichloroethylene were lower in 2013 than in 2011. However, the oxychlordane concentration was lowest in 2011. The serum levels of most lipophilic POPs followed downward trends during the study period, which was expected, as these compounds has been banned for many years. The upward trend of oxychlordane was unexpected and presumably a chance finding.

AB - The use of the lipophilic persistent organic pollutants (POPs) including polychlorinated biphenyls (PCBs) and several organochlorine pesticides (OCPs) has been prohibited for more than 30 years. In this study, we present the temporal trends of the lipophilic POP serum concentrations in Danish nulliparous pregnant women between 2011 and 2013. We randomly selected 197 pregnant women (gestational age 11-13) from the Aarhus Birth Cohort. The concentrations of the lipophilic POPs in the serum samples were analyzed using gas chromatography. The concentrations were corrected for total serum lipids. The statistical analysis was performed by regression analysis with adjustment for age, BMI, gestational age at blood draw, and smoking status. The serum concentrations of PCB 118, 138, 153, 156, 170, 180, 187, and hexachlorobenzen, trans-nonachlor, β-hexachlorocyclohexane (β-HCH), and p,p'-dichlorodiphenyldichloroethylene were lower in 2013 than in 2011. However, the oxychlordane concentration was lowest in 2011. The serum levels of most lipophilic POPs followed downward trends during the study period, which was expected, as these compounds has been banned for many years. The upward trend of oxychlordane was unexpected and presumably a chance finding.

KW - determinants

KW - organochlorine pesticides

KW - polychlorinated biphenyls

KW - predictors

KW - pregnancy

KW - time trends

U2 - 10.1007/s11356-017-8992-7

DO - 10.1007/s11356-017-8992-7

M3 - Journal article

C2 - 28432626

SN - 0944-1344

VL - 24

SP - 16592

EP - 16603

JO - Environmental Science and Pollution Research

JF - Environmental Science and Pollution Research

IS - 20

ER -