Technical Comment on “Inhibition mechanism of NKCC1 involves the carboxyl terminus and long-range conformational coupling”

Rasmus Kock Flygaard; Michael Habeck; Poul Nissen

doi:10.1126/sciadv.adh0821

Technical Comment on “Inhibition mechanism of NKCC1 involves the carboxyl terminus and long-range conformational coupling”

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Comment/debate/letter to the editor › Research › peer-review

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Abstract

Flygaard, Habeck and Nissen question claims on bumetanide and furosemide binding to sodium-potassium-chloride cotransporter NKCC1.

Original language	English
Article number	adh0821
Journal	Science Advances
Volume	9
Issue	28
ISSN	2375-2548
DOIs	https://doi.org/10.1126/sciadv.adh0821
Publication status	Published - 12 Jul 2023

Keywords

Bumetanide/pharmacology
Furosemide
Molecular Conformation

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10.1126/sciadv.adh0821

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title = "Technical Comment on “Inhibition mechanism of NKCC1 involves the carboxyl terminus and long-range conformational coupling”",

abstract = "Flygaard, Habeck and Nissen question claims on bumetanide and furosemide binding to sodium-potassium-chloride cotransporter NKCC1.",

keywords = "Bumetanide/pharmacology, Furosemide, Molecular Conformation",

author = "Flygaard, \{Rasmus Kock\} and Michael Habeck and Poul Nissen",

year = "2023",

month = jul,

day = "12",

doi = "10.1126/sciadv.adh0821",

language = "English",

volume = "9",

journal = "Science Advances",

issn = "2375-2548",

publisher = "American Association for the Advancement of Science",

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Technical Comment on “Inhibition mechanism of NKCC1 involves the carboxyl terminus and long-range conformational coupling”. / Flygaard, Rasmus Kock; Habeck, Michael; Nissen, Poul.
In: Science Advances, Vol. 9, No. 28, adh0821, 12.07.2023.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Comment/debate/letter to the editor › Research › peer-review

TY - JOUR

T1 - Technical Comment on “Inhibition mechanism of NKCC1 involves the carboxyl terminus and long-range conformational coupling”

AU - Flygaard, Rasmus Kock

AU - Habeck, Michael

AU - Nissen, Poul

PY - 2023/7/12

Y1 - 2023/7/12

N2 - Flygaard, Habeck and Nissen question claims on bumetanide and furosemide binding to sodium-potassium-chloride cotransporter NKCC1.

AB - Flygaard, Habeck and Nissen question claims on bumetanide and furosemide binding to sodium-potassium-chloride cotransporter NKCC1.

KW - Bumetanide/pharmacology

KW - Furosemide

KW - Molecular Conformation

U2 - 10.1126/sciadv.adh0821

DO - 10.1126/sciadv.adh0821

M3 - Comment/debate/letter to the editor

C2 - 37436990

SN - 2375-2548

VL - 9

JO - Science Advances

JF - Science Advances

IS - 28

M1 - adh0821

ER -

Technical Comment on “Inhibition mechanism of NKCC1 involves the carboxyl terminus and long-range conformational coupling”

Abstract

Keywords

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