Tea and coffee consumption and risk of esophageal cancer: the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Raul Zamora-Ros; Leila Luján-Barroso; H Bas Bueno-de-Mesquita; Vincent K Dik; Heiner Boeing; Annika Steffen; Anne Tjønneland; Anja Viendahl Olsen; Bodil Hammer Bech; Kim Overvad; Marie-Christine Boutron-Ruault; Antoine Racine; Guy Fagherazzi; Tilman Kuhn; Verena Katzke; Antonia Trichopoulou; Pagona Lagiou; Dimitrios Trichopoulos; Rosario Tumino; Salvatore Panico; Paolo Vineis; Sara Grioni; Domenico Palli; Elisabete Weiderpass; Guri Skeie; José María Huerta; María-José Sánchez; Marcial Argüelles; Pilar Amiano; Eva Ardanaz; Lena Nilsson; Bengt Wallner; Björn Lindkvist; Peter Wallström; Petra H M Peeters; Timothy J Key; Kay-Thee Khaw; Nicholas J Wareham; Heinz Freisling; Magdalena Stepien; Pietro Ferrari; Marc J Gunter; Neil Murphy; Elio Riboli; Carlos A González

doi:10.1002/ijc.28789

Tea and coffee consumption and risk of esophageal cancer: the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Raul Zamora-Ros, Leila Luján-Barroso, H Bas Bueno-de-Mesquita, Vincent K Dik, Heiner Boeing, Annika Steffen, Anne Tjønneland, Anja Viendahl Olsen, Bodil Hammer Bech, Kim Overvad, Marie-Christine Boutron-Ruault, Antoine Racine, Guy Fagherazzi, Tilman Kuhn, Verena Katzke, Antonia Trichopoulou, Pagona Lagiou, Dimitrios Trichopoulos, Rosario Tumino, Salvatore PanicoPaolo Vineis, Sara Grioni, Domenico Palli, Elisabete Weiderpass, Guri Skeie, José María Huerta, María-José Sánchez, Marcial Argüelles, Pilar Amiano, Eva Ardanaz, Lena Nilsson, Bengt Wallner, Björn Lindkvist, Peter Wallström, Petra H M Peeters, Timothy J Key, Kay-Thee Khaw, Nicholas J Wareham, Heinz Freisling, Magdalena Stepien, Pietro Ferrari, Marc J Gunter, Neil Murphy, Elio Riboli, Carlos A González

Department of Public Health - Department of Epidemiology

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Abstract

Epidemiological data regarding tea and coffee consumption and risk of esophageal cancer (EC) is still inconclusive. We examined the association of tea and coffee consumption with EC risk among 442,143 men and women without cancer at baseline from 9 countries of the European Prospective Investigation into Cancer and Nutrition (EPIC). Tea and coffee intakes were recorded using country-specific validated dietary questionnaires. Cox regression models were used to analyze the relationships between tea and coffee intake and EC risk. During a mean follow-up of 11.1 years, 339 participants developed EC, of which 142 were esophageal adenocarcinoma (EAC) and 174 were esophageal squamous cell carcinoma (ESCC). In the multivariable models, no significant associations between tea (mostly black tea), and coffee intake and risk of EC, EAC and ESCC were observed. In stratified analyses, among men coffee consumption was inversely related to ESCC (HR for comparison of extreme tertiles 0.42, 95% CI 0.20-0.88; P-trend=0.022), but not among women. In current smokers, a significant and inverse association was observed between ESCC risk and tea (HR 0.46, 95% CI 0.23-0.93; P-trend=0.053) and coffee consumption (HR 0.37, 95% CI 0.19-0.73; P-trend=0.011). However, no statistically significant findings were observed using the continuous variable (per 100mL/d). These data did not show a significant association between tea and coffee consumption and EC, EAC and ESCC, although a decreased risk of ESCC among men and current smokers is suggested, but need to be confirmed in further prospective studies including more cases. © 2014 Wiley Periodicals, Inc.

Original language	English
Journal	International Journal of Cancer
Volume	135
Issue	6
Pages (from-to)	1470-9
ISSN	0020-7136
DOIs	https://doi.org/10.1002/ijc.28789
Publication status	Published - 15 Sept 2014

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Zamora-Ros, R., Luján-Barroso, L., Bueno-de-Mesquita, H. B., Dik, V. K., Boeing, H., Steffen, A., Tjønneland, A., Olsen, A. V., Bech, B. H., Overvad, K., Boutron-Ruault, M.-C., Racine, A., Fagherazzi, G., Kuhn, T., Katzke, V., Trichopoulou, A., Lagiou, P., Trichopoulos, D., Tumino, R., ... González, C. A. (2014). Tea and coffee consumption and risk of esophageal cancer: the European Prospective Investigation into Cancer and Nutrition (EPIC) study. International Journal of Cancer, 135(6), 1470-9. https://doi.org/10.1002/ijc.28789

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title = "Tea and coffee consumption and risk of esophageal cancer: the European Prospective Investigation into Cancer and Nutrition (EPIC) study",

abstract = "Epidemiological data regarding tea and coffee consumption and risk of esophageal cancer (EC) is still inconclusive. We examined the association of tea and coffee consumption with EC risk among 442,143 men and women without cancer at baseline from 9 countries of the European Prospective Investigation into Cancer and Nutrition (EPIC). Tea and coffee intakes were recorded using country-specific validated dietary questionnaires. Cox regression models were used to analyze the relationships between tea and coffee intake and EC risk. During a mean follow-up of 11.1 years, 339 participants developed EC, of which 142 were esophageal adenocarcinoma (EAC) and 174 were esophageal squamous cell carcinoma (ESCC). In the multivariable models, no significant associations between tea (mostly black tea), and coffee intake and risk of EC, EAC and ESCC were observed. In stratified analyses, among men coffee consumption was inversely related to ESCC (HR for comparison of extreme tertiles 0.42, 95% CI 0.20-0.88; P-trend=0.022), but not among women. In current smokers, a significant and inverse association was observed between ESCC risk and tea (HR 0.46, 95% CI 0.23-0.93; P-trend=0.053) and coffee consumption (HR 0.37, 95% CI 0.19-0.73; P-trend=0.011). However, no statistically significant findings were observed using the continuous variable (per 100mL/d). These data did not show a significant association between tea and coffee consumption and EC, EAC and ESCC, although a decreased risk of ESCC among men and current smokers is suggested, but need to be confirmed in further prospective studies including more cases. {\textcopyright} 2014 Wiley Periodicals, Inc.",

author = "Raul Zamora-Ros and Leila Luj{\'a}n-Barroso and Bueno-de-Mesquita, {H Bas} and Dik, {Vincent K} and Heiner Boeing and Annika Steffen and Anne Tj{\o}nneland and Olsen, {Anja Viendahl} and Bech, {Bodil Hammer} and Kim Overvad and Marie-Christine Boutron-Ruault and Antoine Racine and Guy Fagherazzi and Tilman Kuhn and Verena Katzke and Antonia Trichopoulou and Pagona Lagiou and Dimitrios Trichopoulos and Rosario Tumino and Salvatore Panico and Paolo Vineis and Sara Grioni and Domenico Palli and Elisabete Weiderpass and Guri Skeie and Huerta, {Jos{\'e} Mar{\'i}a} and Mar{\'i}a-Jos{\'e} S{\'a}nchez and Marcial Arg{\"u}elles and Pilar Amiano and Eva Ardanaz and Lena Nilsson and Bengt Wallner and Bj{\"o}rn Lindkvist and Peter Wallstr{\"o}m and Peeters, {Petra H M} and Key, {Timothy J} and Kay-Thee Khaw and Wareham, {Nicholas J} and Heinz Freisling and Magdalena Stepien and Pietro Ferrari and Gunter, {Marc J} and Neil Murphy and Elio Riboli and Gonz{\'a}lez, {Carlos A}",

note = "Copyright {\textcopyright} 2014 UICC.",

year = "2014",

month = sep,

day = "15",

doi = "10.1002/ijc.28789",

language = "English",

volume = "135",

pages = "1470--9",

journal = "International Journal of Cancer",

issn = "0020-7136",

publisher = "John Wiley & Sons Inc.",

number = "6",

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Zamora-Ros, R, Luján-Barroso, L, Bueno-de-Mesquita, HB, Dik, VK, Boeing, H, Steffen, A, Tjønneland, A, Olsen, AV , Bech, BH, Overvad, K, Boutron-Ruault, M-C, Racine, A, Fagherazzi, G, Kuhn, T, Katzke, V, Trichopoulou, A, Lagiou, P, Trichopoulos, D, Tumino, R, Panico, S, Vineis, P, Grioni, S, Palli, D, Weiderpass, E, Skeie, G, Huerta, JM, Sánchez, M-J, Argüelles, M, Amiano, P, Ardanaz, E, Nilsson, L, Wallner, B, Lindkvist, B, Wallström, P, Peeters, PHM, Key, TJ, Khaw, K-T, Wareham, NJ, Freisling, H, Stepien, M, Ferrari, P, Gunter, MJ, Murphy, N, Riboli, E & González, CA 2014, 'Tea and coffee consumption and risk of esophageal cancer: the European Prospective Investigation into Cancer and Nutrition (EPIC) study', International Journal of Cancer, vol. 135, no. 6, pp. 1470-9. https://doi.org/10.1002/ijc.28789

Tea and coffee consumption and risk of esophageal cancer: the European Prospective Investigation into Cancer and Nutrition (EPIC) study. / Zamora-Ros, Raul; Luján-Barroso, Leila; Bueno-de-Mesquita, H Bas et al.
In: International Journal of Cancer, Vol. 135, No. 6, 15.09.2014, p. 1470-9.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

TY - JOUR

T1 - Tea and coffee consumption and risk of esophageal cancer

T2 - the European Prospective Investigation into Cancer and Nutrition (EPIC) study

AU - Zamora-Ros, Raul

AU - Luján-Barroso, Leila

AU - Bueno-de-Mesquita, H Bas

AU - Dik, Vincent K

AU - Boeing, Heiner

AU - Steffen, Annika

AU - Tjønneland, Anne

AU - Olsen, Anja Viendahl

AU - Bech, Bodil Hammer

AU - Overvad, Kim

AU - Boutron-Ruault, Marie-Christine

AU - Racine, Antoine

AU - Fagherazzi, Guy

AU - Kuhn, Tilman

AU - Katzke, Verena

AU - Trichopoulou, Antonia

AU - Lagiou, Pagona

AU - Trichopoulos, Dimitrios

AU - Tumino, Rosario

AU - Panico, Salvatore

AU - Vineis, Paolo

AU - Grioni, Sara

AU - Palli, Domenico

AU - Weiderpass, Elisabete

AU - Skeie, Guri

AU - Huerta, José María

AU - Sánchez, María-José

AU - Argüelles, Marcial

AU - Amiano, Pilar

AU - Ardanaz, Eva

AU - Nilsson, Lena

AU - Wallner, Bengt

AU - Lindkvist, Björn

AU - Wallström, Peter

AU - Peeters, Petra H M

AU - Key, Timothy J

AU - Khaw, Kay-Thee

AU - Wareham, Nicholas J

AU - Freisling, Heinz

AU - Stepien, Magdalena

AU - Ferrari, Pietro

AU - Gunter, Marc J

AU - Murphy, Neil

AU - Riboli, Elio

AU - González, Carlos A

PY - 2014/9/15

Y1 - 2014/9/15

N2 - Epidemiological data regarding tea and coffee consumption and risk of esophageal cancer (EC) is still inconclusive. We examined the association of tea and coffee consumption with EC risk among 442,143 men and women without cancer at baseline from 9 countries of the European Prospective Investigation into Cancer and Nutrition (EPIC). Tea and coffee intakes were recorded using country-specific validated dietary questionnaires. Cox regression models were used to analyze the relationships between tea and coffee intake and EC risk. During a mean follow-up of 11.1 years, 339 participants developed EC, of which 142 were esophageal adenocarcinoma (EAC) and 174 were esophageal squamous cell carcinoma (ESCC). In the multivariable models, no significant associations between tea (mostly black tea), and coffee intake and risk of EC, EAC and ESCC were observed. In stratified analyses, among men coffee consumption was inversely related to ESCC (HR for comparison of extreme tertiles 0.42, 95% CI 0.20-0.88; P-trend=0.022), but not among women. In current smokers, a significant and inverse association was observed between ESCC risk and tea (HR 0.46, 95% CI 0.23-0.93; P-trend=0.053) and coffee consumption (HR 0.37, 95% CI 0.19-0.73; P-trend=0.011). However, no statistically significant findings were observed using the continuous variable (per 100mL/d). These data did not show a significant association between tea and coffee consumption and EC, EAC and ESCC, although a decreased risk of ESCC among men and current smokers is suggested, but need to be confirmed in further prospective studies including more cases. © 2014 Wiley Periodicals, Inc.

AB - Epidemiological data regarding tea and coffee consumption and risk of esophageal cancer (EC) is still inconclusive. We examined the association of tea and coffee consumption with EC risk among 442,143 men and women without cancer at baseline from 9 countries of the European Prospective Investigation into Cancer and Nutrition (EPIC). Tea and coffee intakes were recorded using country-specific validated dietary questionnaires. Cox regression models were used to analyze the relationships between tea and coffee intake and EC risk. During a mean follow-up of 11.1 years, 339 participants developed EC, of which 142 were esophageal adenocarcinoma (EAC) and 174 were esophageal squamous cell carcinoma (ESCC). In the multivariable models, no significant associations between tea (mostly black tea), and coffee intake and risk of EC, EAC and ESCC were observed. In stratified analyses, among men coffee consumption was inversely related to ESCC (HR for comparison of extreme tertiles 0.42, 95% CI 0.20-0.88; P-trend=0.022), but not among women. In current smokers, a significant and inverse association was observed between ESCC risk and tea (HR 0.46, 95% CI 0.23-0.93; P-trend=0.053) and coffee consumption (HR 0.37, 95% CI 0.19-0.73; P-trend=0.011). However, no statistically significant findings were observed using the continuous variable (per 100mL/d). These data did not show a significant association between tea and coffee consumption and EC, EAC and ESCC, although a decreased risk of ESCC among men and current smokers is suggested, but need to be confirmed in further prospective studies including more cases. © 2014 Wiley Periodicals, Inc.

U2 - 10.1002/ijc.28789

DO - 10.1002/ijc.28789

M3 - Journal article

C2 - 24535727

SN - 0020-7136

VL - 135

SP - 1470

EP - 1479

JO - International Journal of Cancer

JF - International Journal of Cancer

IS - 6

ER -

Tea and coffee consumption and risk of esophageal cancer: the European Prospective Investigation into Cancer and Nutrition (EPIC) study

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