Taste receptors in the gut – A new target for health promoting properties in diet

Bo Ekstrand; Jette Feveile Young; Martin Krøyer Rasmussen

doi:10.1016/j.foodres.2017.08.024

Taste receptors in the gut – A new target for health promoting properties in diet

Bo Ekstrand, Jette Feveile Young, Martin Krøyer Rasmussen

Department of Food Science - Differentiated & Biofunctional Foods

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

26 Citations (Scopus)

Abstract

In this review we describe a new target for food functionality, the taste receptors in the gastrointestinal tract. These receptors are involved in an intricate signalling network for monitoring of taste and nutrient intake, homeostasis and energy metabolism, and they are also an early warning system for toxic substances in our diet. Especially the receptors for bitter taste provide a new possibility to activate a number of health related signalling pathways, already at low concentrations of the active substance, without requiring uptake into the body and transport via the circulation. When ligands bind to these receptors, signalling is induced either via peptide hormones into the circulation to other organs in the body, or via nerve fibers directly to the brain.

Original language	English
Journal	Food Research International
Volume	100
Issue	2
Pages (from-to)	1-8
Number of pages	8
ISSN	0963-9969
DOIs	https://doi.org/10.1016/j.foodres.2017.08.024
Publication status	Published - Oct 2017

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title = "Taste receptors in the gut – A new target for health promoting properties in diet",

abstract = "In this review we describe a new target for food functionality, the taste receptors in the gastrointestinal tract. These receptors are involved in an intricate signalling network for monitoring of taste and nutrient intake, homeostasis and energy metabolism, and they are also an early warning system for toxic substances in our diet. Especially the receptors for bitter taste provide a new possibility to activate a number of health related signalling pathways, already at low concentrations of the active substance, without requiring uptake into the body and transport via the circulation. When ligands bind to these receptors, signalling is induced either via peptide hormones into the circulation to other organs in the body, or via nerve fibers directly to the brain.",

keywords = "Cell – cell signalling, Crosstalk, Functional food, Taste, Taste receptors",

author = "Bo Ekstrand and Young, \{Jette Feveile\} and Rasmussen, \{Martin Kr{\o}yer\}",

year = "2017",

month = oct,

doi = "10.1016/j.foodres.2017.08.024",

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AU - Ekstrand, Bo

AU - Young, Jette Feveile

AU - Rasmussen, Martin Krøyer

PY - 2017/10

Y1 - 2017/10

N2 - In this review we describe a new target for food functionality, the taste receptors in the gastrointestinal tract. These receptors are involved in an intricate signalling network for monitoring of taste and nutrient intake, homeostasis and energy metabolism, and they are also an early warning system for toxic substances in our diet. Especially the receptors for bitter taste provide a new possibility to activate a number of health related signalling pathways, already at low concentrations of the active substance, without requiring uptake into the body and transport via the circulation. When ligands bind to these receptors, signalling is induced either via peptide hormones into the circulation to other organs in the body, or via nerve fibers directly to the brain.

AB - In this review we describe a new target for food functionality, the taste receptors in the gastrointestinal tract. These receptors are involved in an intricate signalling network for monitoring of taste and nutrient intake, homeostasis and energy metabolism, and they are also an early warning system for toxic substances in our diet. Especially the receptors for bitter taste provide a new possibility to activate a number of health related signalling pathways, already at low concentrations of the active substance, without requiring uptake into the body and transport via the circulation. When ligands bind to these receptors, signalling is induced either via peptide hormones into the circulation to other organs in the body, or via nerve fibers directly to the brain.

KW - Cell – cell signalling

KW - Crosstalk

KW - Functional food

KW - Taste

KW - Taste receptors

UR - https://www.scopus.com/pages/publications/85027525578

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DO - 10.1016/j.foodres.2017.08.024

M3 - Journal article

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SN - 0963-9969

VL - 100

SP - 1

EP - 8

JO - Food Research International

JF - Food Research International

IS - 2

ER -

Taste receptors in the gut – A new target for health promoting properties in diet

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