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Synthetic developments on the preparation of sulfides from thiol-free reagents

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  • Gabriel M.F. Batista
  • Pedro P. De Castro, Universidade Federal de Juiz de Fora
  • ,
  • Juliana A. Dos Santos, Universidade Federal de Juiz de Fora
  • ,
  • Troels Skrydstrup
  • Giovanni W. Amarante, Universidade Federal de Juiz de Fora

Thiols are known for their strong odor and high toxicity, which makes the development of thiol-free alternatives for the construction of sulfur-containing derivatives, in particular sulfides (thioethers), highly desirable. Over the last few years, several approaches for the preparation of these compounds from alternative sources, such as DMSO, disulfides, elemental sulfur, Bunte salts, and N-substituted sulfanylsuccinimides, have been described. This critical review presents an in-depth analysis of the preparation of these derivatives, including the presentation of selected examples and the careful discussion of mechanistic pathways.

Original languageEnglish
JournalOrganic Chemistry Frontiers
Pages (from-to)326-368
Number of pages43
Publication statusPublished - Jan 2021

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