SYNTHESIS AND HYDROLYSIS OF NEW ASPIRIN-DERIVED AND TRIFLUSAL-DERIVED ORTHO ESTERS AND ANHYDRIDES

L FALBORG, A SENNING

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Abstract

Ten new 2-substituted 2-methyl-2-oxy-4H-1,3-benzodioxin-4-ones, 4a-i and 6, have been synthesized and their rate constants of pseudo-first-order non-enzymatic hydrolysis determined. One of the compounds, 2-(2-acetoxybenzoyloxy)-2-methyl-4H-1,3-benzodioxin-4-one, 6, is a new anhydride of aspirin. The analogous triflusal derivative, 10, has also been synthesized.

Original languageEnglish
JournalDalton Transactions (Print Edition)
Volume47
Issue5
Pages (from-to)514-520
Number of pages7
ISSN0904-213X
Publication statusPublished - May 1993

Keywords

  • BIOLOGICAL-MEMBRANES
  • ACETYLSALICYLIC-ACID
  • IMPROVED DELIVERY
  • PRODRUGS
  • 2-ACETOXYBENZOATE
  • MECHANISM

Fingerprint

Dive into the research topics of 'SYNTHESIS AND HYDROLYSIS OF NEW ASPIRIN-DERIVED AND TRIFLUSAL-DERIVED ORTHO ESTERS AND ANHYDRIDES'. Together they form a unique fingerprint.

Cite this