Susceptibility to Leprosy is Associated with M-ficolin Polymorphisms

Angelica B W Boldt, Maria Iolanda N Sanchez, Ewalda R S Stahlke, Rudi Steffensen, Steffen Thiel, Jens C Jensenius, Flávia Costa Prevedello, Marcelo Távora Mira, Jürgen F J Kun, Iara J T Messias-Reason

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Abstract

Mycobacterium leprae exploits complement activation and opsonophagocytosis to infect phagocytes. M-ficolin is encoded by the FCN1 gene and initiates the lectin pathway on monocyte surfaces. We investigated FCN1 promoter polymorphisms that could be responsible for the high interindividual variability of M-ficolin levels and for modulating leprosy susceptibility.
Original languageEnglish
JournalJournal of Clinical Immunology
Volume33
Issue1
Pages (from-to)210-9
Number of pages10
ISSN0271-9142
DOIs
Publication statusPublished - 2013

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