Surface recrystallization on melt electrowritten scaffolds for acceleration of osteogenic differentiation

Yingchun Su; Yuge Zhang; Yang Chen; Sara Seidelin Majidi; Mingdong Dong; Menglin Chen

doi:10.1016/j.mtphys.2024.101344

Surface recrystallization on melt electrowritten scaffolds for acceleration of osteogenic differentiation

Yingchun Su, Yuge Zhang, Yang Chen, Sara Seidelin Majidi, Mingdong Dong, Menglin Chen^*

^*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

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Abstract

As physical topographical features suggest important effects in bone tissue engineering, an increasing amount of research on surface topographies has been carried out. In this work, melt electrowritten PCL scaffolds (mPCL) with recrystallized surfaces for osteogenic differentiation were constructed. The recrystallized grid PCL scaffolds (rPCL) show strengthened mechanical properties, retained biocompatibility, enhanced expression of alkaline phosphatase, and improved calcium mineralization compared to uncrystallized mPCL scaffolds, thereby confirming the promotion of osteogenic differentiation. In addition, lumbar vertebra-like rPCL scaffolds were successfully printed for precursor osteoblast-like cells to cellularize in the desired pattern. Importantly, the combination of recrystallization method and MEW technology introduced new function into the MEW based tissue engineering scaffolds, presenting the nano/microstructure of PCL on macroscale PCL scaffolds with enhanced osteogenic activities, which especially opens a new facile route for MEW scaffolds to broaden their applications in bone tissue engineering.

Original language	English
Article number	101344
Journal	Materials Today Physics
Volume	41
ISSN	2542-5293
DOIs	https://doi.org/10.1016/j.mtphys.2024.101344
Publication status	Published - Feb 2024

Keywords

Lumbar vertebra-like scaffold
Melt electrowriting
Osteogenic differentiation
Polycaprolactone
Surface recrystallization

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10.1016/j.mtphys.2024.101344

1-s2.0-S2542529324000208-mainFinal published version, 8.38 MBLicence: CC BY

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title = "Surface recrystallization on melt electrowritten scaffolds for acceleration of osteogenic differentiation",

abstract = "As physical topographical features suggest important effects in bone tissue engineering, an increasing amount of research on surface topographies has been carried out. In this work, melt electrowritten PCL scaffolds (mPCL) with recrystallized surfaces for osteogenic differentiation were constructed. The recrystallized grid PCL scaffolds (rPCL) show strengthened mechanical properties, retained biocompatibility, enhanced expression of alkaline phosphatase, and improved calcium mineralization compared to uncrystallized mPCL scaffolds, thereby confirming the promotion of osteogenic differentiation. In addition, lumbar vertebra-like rPCL scaffolds were successfully printed for precursor osteoblast-like cells to cellularize in the desired pattern. Importantly, the combination of recrystallization method and MEW technology introduced new function into the MEW based tissue engineering scaffolds, presenting the nano/microstructure of PCL on macroscale PCL scaffolds with enhanced osteogenic activities, which especially opens a new facile route for MEW scaffolds to broaden their applications in bone tissue engineering.",

keywords = "Lumbar vertebra-like scaffold, Melt electrowriting, Osteogenic differentiation, Polycaprolactone, Surface recrystallization",

author = "Yingchun Su and Yuge Zhang and Yang Chen and Majidi, {Sara Seidelin} and Mingdong Dong and Menglin Chen",

note = "Publisher Copyright: {\textcopyright} 2024 The Authors",

year = "2024",

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doi = "10.1016/j.mtphys.2024.101344",

language = "English",

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T1 - Surface recrystallization on melt electrowritten scaffolds for acceleration of osteogenic differentiation

AU - Su, Yingchun

AU - Zhang, Yuge

AU - Chen, Yang

AU - Majidi, Sara Seidelin

AU - Dong, Mingdong

AU - Chen, Menglin

PY - 2024/2

Y1 - 2024/2

N2 - As physical topographical features suggest important effects in bone tissue engineering, an increasing amount of research on surface topographies has been carried out. In this work, melt electrowritten PCL scaffolds (mPCL) with recrystallized surfaces for osteogenic differentiation were constructed. The recrystallized grid PCL scaffolds (rPCL) show strengthened mechanical properties, retained biocompatibility, enhanced expression of alkaline phosphatase, and improved calcium mineralization compared to uncrystallized mPCL scaffolds, thereby confirming the promotion of osteogenic differentiation. In addition, lumbar vertebra-like rPCL scaffolds were successfully printed for precursor osteoblast-like cells to cellularize in the desired pattern. Importantly, the combination of recrystallization method and MEW technology introduced new function into the MEW based tissue engineering scaffolds, presenting the nano/microstructure of PCL on macroscale PCL scaffolds with enhanced osteogenic activities, which especially opens a new facile route for MEW scaffolds to broaden their applications in bone tissue engineering.

AB - As physical topographical features suggest important effects in bone tissue engineering, an increasing amount of research on surface topographies has been carried out. In this work, melt electrowritten PCL scaffolds (mPCL) with recrystallized surfaces for osteogenic differentiation were constructed. The recrystallized grid PCL scaffolds (rPCL) show strengthened mechanical properties, retained biocompatibility, enhanced expression of alkaline phosphatase, and improved calcium mineralization compared to uncrystallized mPCL scaffolds, thereby confirming the promotion of osteogenic differentiation. In addition, lumbar vertebra-like rPCL scaffolds were successfully printed for precursor osteoblast-like cells to cellularize in the desired pattern. Importantly, the combination of recrystallization method and MEW technology introduced new function into the MEW based tissue engineering scaffolds, presenting the nano/microstructure of PCL on macroscale PCL scaffolds with enhanced osteogenic activities, which especially opens a new facile route for MEW scaffolds to broaden their applications in bone tissue engineering.

KW - Lumbar vertebra-like scaffold

KW - Melt electrowriting

KW - Osteogenic differentiation

KW - Polycaprolactone

KW - Surface recrystallization

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DO - 10.1016/j.mtphys.2024.101344

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SN - 2542-5293

VL - 41

JO - Materials Today Physics

JF - Materials Today Physics

M1 - 101344

ER -

Surface recrystallization on melt electrowritten scaffolds for acceleration of osteogenic differentiation

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Keywords

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