Surface recrystallization on melt electrowritten scaffolds for acceleration of osteogenic differentiation

Yingchun Su, Yuge Zhang, Yang Chen, Sara Seidelin Majidi, Mingdong Dong, Menglin Chen*

*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Abstract

As physical topographical features suggest important effects in bone tissue engineering, an increasing amount of research on surface topographies has been carried out. In this work, melt electrowritten PCL scaffolds (mPCL) with recrystallized surfaces for osteogenic differentiation were constructed. The recrystallized grid PCL scaffolds (rPCL) show strengthened mechanical properties, retained biocompatibility, enhanced expression of alkaline phosphatase, and improved calcium mineralization compared to uncrystallized mPCL scaffolds, thereby confirming the promotion of osteogenic differentiation. In addition, lumbar vertebra-like rPCL scaffolds were successfully printed for precursor osteoblast-like cells to cellularize in the desired pattern. Importantly, the combination of recrystallization method and MEW technology introduced new function into the MEW based tissue engineering scaffolds, presenting the nano/microstructure of PCL on macroscale PCL scaffolds with enhanced osteogenic activities, which especially opens a new facile route for MEW scaffolds to broaden their applications in bone tissue engineering.

Original languageEnglish
Article number101344
JournalMaterials Today Physics
Volume41
ISSN2542-5293
DOIs
Publication statusPublished - Feb 2024

Keywords

  • Lumbar vertebra-like scaffold
  • Melt electrowriting
  • Osteogenic differentiation
  • Polycaprolactone
  • Surface recrystallization

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