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Superinfection exclusion studies using West Nile virus and Culex flavivirus strains from Argentina

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  • Silvina Goenaga, Universidad Nacional del Noroeste de la Provincia de Buenos Aires
  • ,
  • Julieta Goenaga
  • ,
  • Estefanía Raquel Boaglio, Universidad Nacional del Noroeste de la Provincia de Buenos Aires
  • ,
  • Delia Alcira Enria
  • ,
  • Silvana del Carmen Levis

In Argentina, many Flavivirus were recognised including West Nile virus (WNV). During 2009 several strains of Culex Flavivirus (CxFV), an insect-specific flavivirus, were isolated in the same region where circulation of WNV was detected. Hence, the objective of this study was to analyse the effect of co-infection in vitro assays using CxFV and WNV Argentinean strains in order to evaluate if CxFV could affect WNV replication. Our results showed that WNV replication was suppressed when multiplicity of infection (MOI) for CxFV was 10 or 100 times higher than WNV. Nevertheless, in vivo assays are necessary in order to evaluate the superinfection exclusion potential.

Original languageEnglish
Article numbere200012
JournalMemorias do Instituto Oswaldo Cruz
Volume115
ISSN0074-0276
DOIs
Publication statusPublished - Mar 2020

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