Substrate recognition and transport mechanism of the PIN-FORMED auxin exporters

Kien Lam Ung, Lukas Schulz, David L. Stokes, Ulrich Z. Hammes, Bjørn Panyella Pedersen*

*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

9 Citations (Scopus)

Abstract

Auxins are pivotal plant hormones that regulate plant growth and transmembrane polar auxin transport (PAT) direct patterns of development. The PIN-FORMED (PIN) family of membrane transporters mediate auxin export from the plant cell and play crucial roles in PAT. Here we describe the recently solved structures of PIN transporters, PIN1, PIN3, and PIN8, and also their mechanisms of substrate recognition and transport of auxin. We compare structures of PINs in both inward- and outward-facing conformations, as well as PINs with different binding configurations for auxin. By this comparative analysis, a model emerges for an elevator transport mechanism. Central structural elements necessary for function are identified, and we show that these are shared with other distantly related protein families.

Original languageEnglish
JournalTrends in Biochemical Sciences
Volume48
Issue11
Pages (from-to)937-948
Number of pages12
ISSN0968-0004
DOIs
Publication statusPublished - Nov 2023

Keywords

  • PIN1
  • PIN3
  • PIN8
  • plant hormones
  • polar auxin transport (PAT)
  • transport mechanism

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