Studying Werner syndrome to elucidate mechanisms and therapeutics of human aging and age-related diseases

Sofie Lautrup; Domenica Caponio; Hoi Hung Cheung; Claudia Piccoli; Tinna Stevnsner; Wai Yee Chan; Evandro F. Fang

doi:10.1007/s10522-019-09798-2

Studying Werner syndrome to elucidate mechanisms and therapeutics of human aging and age-related diseases

Sofie Lautrup, Domenica Caponio, Hoi Hung Cheung, Claudia Piccoli, Tinna Stevnsner, Wai Yee Chan, Evandro F. Fang^*

^*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

23 Citations (Scopus)

Abstract

Aging is a natural and unavoidable part of life. However, aging is also the primary driver of the dominant human diseases, such as cardiovascular disease, cancer, and neurodegenerative diseases, including Alzheimer’s disease. Unraveling the sophisticated molecular mechanisms of the human aging process may provide novel strategies to extend ‘healthy aging’ and the cure of human aging-related diseases. Werner syndrome (WS), is a heritable human premature aging disease caused by mutations in the gene encoding the Werner (WRN) DNA helicase. As a classical premature aging disease, etiological exploration of WS can shed light on the mechanisms of normal human aging and facilitate the development of interventional strategies to improve healthspan. Here, we summarize the latest progress of the molecular understandings of WRN protein, highlight the advantages of using different WS model systems, including Caenorhabditis elegans, Drosophila melanogaster and induced pluripotent stem cell (iPSC) systems. Further studies on WS will propel drug development for WS patients, and possibly also for normal age-related diseases.

Original language	English
Journal	Biogerontology
Volume	20
Issue	3
Pages (from-to)	255-269
Number of pages	15
ISSN	1389-5729
DOIs	https://doi.org/10.1007/s10522-019-09798-2
Publication status	Published - Jun 2019

Keywords

Aging
DNA repair
Hallmarkers of aging
Mitophagy
NAD
Premature aging
Werner syndrome
VITAMIN-C
LIFE-SPAN
SYNDROME FIBROBLASTS
DNA-DAMAGE
DOWN-REGULATION
SYNDROME PROTEIN
ELEGANS WRN HELICASE
NUCLEAR-LOCALIZATION
GENE
NAD(+)
STEM-CELL MODEL

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title = "Studying Werner syndrome to elucidate mechanisms and therapeutics of human aging and age-related diseases",

abstract = "Aging is a natural and unavoidable part of life. However, aging is also the primary driver of the dominant human diseases, such as cardiovascular disease, cancer, and neurodegenerative diseases, including Alzheimer{\textquoteright}s disease. Unraveling the sophisticated molecular mechanisms of the human aging process may provide novel strategies to extend {\textquoteleft}healthy aging{\textquoteright} and the cure of human aging-related diseases. Werner syndrome (WS), is a heritable human premature aging disease caused by mutations in the gene encoding the Werner (WRN) DNA helicase. As a classical premature aging disease, etiological exploration of WS can shed light on the mechanisms of normal human aging and facilitate the development of interventional strategies to improve healthspan. Here, we summarize the latest progress of the molecular understandings of WRN protein, highlight the advantages of using different WS model systems, including Caenorhabditis elegans, Drosophila melanogaster and induced pluripotent stem cell (iPSC) systems. Further studies on WS will propel drug development for WS patients, and possibly also for normal age-related diseases.",

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author = "Sofie Lautrup and Domenica Caponio and Cheung, {Hoi Hung} and Claudia Piccoli and Tinna Stevnsner and Chan, {Wai Yee} and Fang, {Evandro F.}",

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AU - Lautrup, Sofie

AU - Caponio, Domenica

AU - Cheung, Hoi Hung

AU - Piccoli, Claudia

AU - Stevnsner, Tinna

AU - Chan, Wai Yee

AU - Fang, Evandro F.

PY - 2019/6

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AB - Aging is a natural and unavoidable part of life. However, aging is also the primary driver of the dominant human diseases, such as cardiovascular disease, cancer, and neurodegenerative diseases, including Alzheimer’s disease. Unraveling the sophisticated molecular mechanisms of the human aging process may provide novel strategies to extend ‘healthy aging’ and the cure of human aging-related diseases. Werner syndrome (WS), is a heritable human premature aging disease caused by mutations in the gene encoding the Werner (WRN) DNA helicase. As a classical premature aging disease, etiological exploration of WS can shed light on the mechanisms of normal human aging and facilitate the development of interventional strategies to improve healthspan. Here, we summarize the latest progress of the molecular understandings of WRN protein, highlight the advantages of using different WS model systems, including Caenorhabditis elegans, Drosophila melanogaster and induced pluripotent stem cell (iPSC) systems. Further studies on WS will propel drug development for WS patients, and possibly also for normal age-related diseases.

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Studying Werner syndrome to elucidate mechanisms and therapeutics of human aging and age-related diseases

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