Structures of benzo(a)pyrene-nucleic acid adducts formed in human and bovine bronchial explants

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DOI

  • A.M. Jeffrey, United States
  • I.B. Weinstein, United States
  • K.W. Jenette, United States
  • K. Grzeskowiak, United States
  • K. Nakanishi, United States
  • R.G. Harvey, United States
  • Herman Autrup
  • C. Harris, United States
  • Institute of Environmental and Occupational Medicine
PUBLICATION by Sims et al. of evidence that the 7,8-dihydrodiol-9,10-oxide of benzo(a)pyrene (BP) is a metabolic intermediate in the covalent binding of this ubiquitous polycyclic aromatic hydrocarbon to DNA in hamster embryo cells1 was followed by many related publications2. Grover et al. 3 also obtained evidence that the same derivative is involved in the binding of BP to the DNA of human bronchial explants, although details of the specific isomer involved and of the structure of the adduct were not reported. We describe here studies on RNA and DNA adducts formed by human bronchial explants and provide evidence that the structures of the major adducts are similar to those formed in the analogous bovine system.
Original languageEnglish
JournalNature
Volume269
Issue5626
Pages (from-to)348-350
Number of pages3
ISSN0028-0836
DOIs
Publication statusPublished - 22 Sep 1977

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