Structural DNA nanotechnology: from design to applications

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  • Reza M Zadegan, Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Denmark
  • Michael L Norton
The exploitation of DNA for the production of nanoscale architectures presents a young yet paradigm breaking approach, which addresses many of the barriers to the self-assembly of small molecules into highly-ordered nanostructures via construct addressability. There are two major methods to construct DNA nanostructures, and in the current review we will discuss the principles and some examples of applications of both the tile-based and DNA origami methods. The tile-based approach is an older method that provides a good tool to construct small and simple structures, usually with multiply repeated domains. In contrast, the origami method, at this time, would appear to be more appropriate for the construction of bigger, more sophisticated and exactly defined structures.
Original languageEnglish
JournalInternational Journal of Molecular Sciences (Online)
Volume13
Issue6
Pages (from-to)7149-62
Number of pages14
ISSN1661-6596
DOIs
Publication statusPublished - 2012

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