Structural conversion of human islet amyloid polypeptide aggregates under an electric field

Yongxiu Song, Rongrong Wu, Yin Wang, Lei Liu*, Mingdong Dong*

*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Abstract

Electric fields (EFs) in biological systems are well known, and their presence implies the activity of protein ion channels and pumps in various cells. The aggregation of islet amyloid polypeptides (IAPP) was recently found in human brain tissue, and this was related to the electrical activity of neurons and caused neuronal loss. However, the association between amyloid formation and the electric field is still unknown. Herein a direct method to stimulate the formation of the hIAPP peptide under an EF is reported.

Original languageEnglish
JournalChemical Communications
Volume56
Issue77
Pages (from-to)11497-11500
Number of pages4
ISSN1359-7345
DOIs
Publication statusPublished - Aug 2020

Keywords

  • ASSEMBLIES
  • BETA PEPTIDE
  • CIRCULAR-DICHROISM
  • DISEASE
  • MODEL
  • NEURON
  • PH
  • PROTEIN SECONDARY STRUCTURE

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