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Strontium functionalized scaffold for bone tissue engineering
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
DOI
- https://doi.org/10.1016/j.msec.2018.09.054
Final published version
- Rahul D. Prabha, University of Southern Denmark, Amrita School of Dentistry ,
- Bindu P. Nair, Sree Chitra Tirunal Institute for Medical Sciences and Technology ,
- Nicholas Ditzel, University of Southern Denmark ,
- Jorgen Kjems
- Prabha D. Nair, Sree Chitra Tirunal Institute for Medical Sciences and Technology ,
- Moustapha Kassem, University of Southern Denmark
Drug functionalized scaffolds are currently being employed to improve local delivery of osteoprotective drugs with the aim of reducing their loading dose as well as unwanted systemic complications. In this study we tested a poly-(ε) caprolactone (PCL)–laponite–strontium ranelate (SRA) composite scaffold (PLS3) for its abilities to support growth and osteogenic differentiation of human marrow derived stromal stem cells (hMSC). The in vitro experiments showed the PLS3 scaffold supported cell growth and osteogenic differentiation. The in vivo implantation of hMSC seeded PLS3 scaffold in immunocompromised mice revealed vascularized ectopic bone formation. PLS3 scaffolds can be useful in bone regenerative applications in the fields of orthopaedics and dentistry.
| Original language | English |
|---|---|
| Journal | Materials Science and Engineering C: Biomimetic Materials, Sensors and Systems |
| Volume | 94 |
| Pages (from-to) | 509-515 |
| Number of pages | 7 |
| ISSN | 0928-4931 |
| DOIs | |
| Publication status | Published - Jan 2019 |
- Laponite, Strontium, Bone, Stem cells, Drug delivery, STEM-CELLS, DELIVERY, DIFFERENTIATION, RANELATE, GRAFTS, CLAY, NANOPARTICLES, GROWTH
Research areas
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