Strontium functionalized scaffold for bone tissue engineering

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  • Rahul D. Prabha, Odense University Hospital, SDU, Amrita School of Dentistry
  • ,
  • Bindu P. Nair, Sree Chitra Tirunal Institute for Medical Sciences and Technology
  • ,
  • Nicholas Ditzel, Odense University Hospital, SDU
  • ,
  • Jorgen Kjems
  • Prabha D. Nair, Sree Chitra Tirunal Institute for Medical Sciences and Technology
  • ,
  • Moustapha Kassem, Odense University Hospital, SDU

Drug functionalized scaffolds are currently being employed to improve local delivery of osteoprotective drugs with the aim of reducing their loading dose as well as unwanted systemic complications. In this study we tested a poly-(ε) caprolactone (PCL)–laponite–strontium ranelate (SRA) composite scaffold (PLS3) for its abilities to support growth and osteogenic differentiation of human marrow derived stromal stem cells (hMSC). The in vitro experiments showed the PLS3 scaffold supported cell growth and osteogenic differentiation. The in vivo implantation of hMSC seeded PLS3 scaffold in immunocompromised mice revealed vascularized ectopic bone formation. PLS3 scaffolds can be useful in bone regenerative applications in the fields of orthopaedics and dentistry.

Original languageEnglish
JournalMaterials Science and Engineering C: Biomimetic Materials, Sensors and Systems
Volume94
Pages (from-to)509-515
Number of pages7
ISSN0928-4931
DOIs
Publication statusPublished - Jan 2019

    Research areas

  • Laponite, Strontium, Bone, Stem cells, Drug delivery, STEM-CELLS, DELIVERY, DIFFERENTIATION, RANELATE, GRAFTS, CLAY, NANOPARTICLES, GROWTH

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