Striatal and extrastriatal dysfunction in Parkinson's disease with dementia: A 6-[18F]fluoro-L-dopa PET study

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DOI

  • Kengo Ito, Department of Biofunctional Research, National Institute for Longevity Sciences
  • ,
  • Atsuko Nagano-Saito, National Institute for Longevity Sciences
  • ,
  • Takashi Kato, National Institute for Longevity Sciences
  • ,
  • Yutaka Arahata, National Institute for Longevity Sciences
  • ,
  • Akinori Nakamura, National Institute for Longevity Sciences
  • ,
  • Yasuhiro Kawasumi, National Institute for Longevity Sciences
  • ,
  • Kentaro Hatano, National Institute for Longevity Sciences
  • ,
  • Yuji Abe, Chubu National Hospital
  • ,
  • Takako Yamada, Chubu National Hospital
  • ,
  • Teruhiko Kachi, Chubu National Hospital
  • ,
  • David J. Brooks

We investigated the relative differences in dopaminergic function through the whole brain in patients with Parkinson's disease without dementia (PD) and with dementia (PDD) using 6-[18F]fluoro-L-dopa (18F-dopa) PET and a voxel-by-voxel analysis. The 10 PD and 10 PDD patients were equivalently disabled, having mean scores of 3.2 ± 0.6 and 3.2 ± 0.7, respectively, on the Hoehn and Yahr rating scale. 18F-dopa influx constant (Ki) images of those patients and 15 normal age-matched subjects were transformed into standard stereotactic space. The significant differences between the groups (expressed in mean regional Ki values) were localized with statistical parametric mapping (SPM) on a voxel-by-voxel basis. Compared with the normal group, SPM localized declines of the 18F-dopa Ki bilaterally in the putamen, the right caudate nucleus and the left ventral midbrain for the PD group (P < 0.01, corrected). Compared with the normal group, the PDD group showed reduced 18F-dopa Ki bilaterally in the striatum, midbrain and anterior cingulate area (P < 0.01, corrected). A relative difference in 18F-dopa uptake between PD and PDD was the bilateral decline in the anterior cingulate area and ventral striatum and in the right caudate nucleus in the PDD group (P < 0.001, corrected). Accordingly, we conclude that dementia in PD is associated with impaired mesolimbic and caudate dopaminergic function.

Original languageEnglish
JournalBrain
Volume125
Issue6
Pages (from-to)1358-1365
Number of pages8
ISSN0006-8950
DOIs
Publication statusPublished - 1 Jan 2002
Externally publishedYes

    Research areas

  • 6-[F]fluoro-L-dopa, Parkinson's disease, Parkinson's disease with dementia, Positron emission tomography

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