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Stoma Formation in Crohn's Disease and the Likelihood of Antidepressant Use: A Population-Based Cohort Study

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Stoma Formation in Crohn's Disease and the Likelihood of Antidepressant Use : A Population-Based Cohort Study. / Blackwell, Jonathan; Saxena, Sonia; Jayasooriya, Nishani et al.

In: Clinical Gastroenterology and Hepatology, Vol. 20, No. 4, 04.2022, p. e703-e710.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Blackwell, J, Saxena, S, Jayasooriya, N, Petersen, I, Hotopf, M, Creese, H, Bottle, A, Pollok, RCG & POP-IBD Study Group 2022, 'Stoma Formation in Crohn's Disease and the Likelihood of Antidepressant Use: A Population-Based Cohort Study', Clinical Gastroenterology and Hepatology, vol. 20, no. 4, pp. e703-e710. https://doi.org/10.1016/j.cgh.2020.12.026

APA

Blackwell, J., Saxena, S., Jayasooriya, N., Petersen, I., Hotopf, M., Creese, H., Bottle, A., Pollok, R. C. G., & POP-IBD Study Group (2022). Stoma Formation in Crohn's Disease and the Likelihood of Antidepressant Use: A Population-Based Cohort Study. Clinical Gastroenterology and Hepatology, 20(4), e703-e710. https://doi.org/10.1016/j.cgh.2020.12.026

CBE

Blackwell J, Saxena S, Jayasooriya N, Petersen I, Hotopf M, Creese H, Bottle A, Pollok RCG, POP-IBD Study Group. 2022. Stoma Formation in Crohn's Disease and the Likelihood of Antidepressant Use: A Population-Based Cohort Study. Clinical Gastroenterology and Hepatology. 20(4):e703-e710. https://doi.org/10.1016/j.cgh.2020.12.026

MLA

Vancouver

Blackwell J, Saxena S, Jayasooriya N, Petersen I, Hotopf M, Creese H et al. Stoma Formation in Crohn's Disease and the Likelihood of Antidepressant Use: A Population-Based Cohort Study. Clinical Gastroenterology and Hepatology. 2022 Apr;20(4):e703-e710. https://doi.org/10.1016/j.cgh.2020.12.026

Author

Blackwell, Jonathan ; Saxena, Sonia ; Jayasooriya, Nishani et al. / Stoma Formation in Crohn's Disease and the Likelihood of Antidepressant Use : A Population-Based Cohort Study. In: Clinical Gastroenterology and Hepatology. 2022 ; Vol. 20, No. 4. pp. e703-e710.

Bibtex

@article{993a3cc135e74e36870e23946c6a7b98,
title = "Stoma Formation in Crohn's Disease and the Likelihood of Antidepressant Use: A Population-Based Cohort Study",
abstract = "Background & Aims: The impact of a temporary or permanent stoma on mental health in Crohn's Disease (CD) is unknown. The aim was to examine the association between intestinal surgery and stoma formation and subsequent antidepressant medication (ADM) use. Methods: Using the Clinical Practice Research Datalink, we identified individuals with CD who underwent intestinal surgery between 1998-2018. We excluded individuals with a prescription for an ADM in the 6 months before surgery. Individuals were stratified into three groups: no stoma, temporary stoma, and permanent stoma. We used Kaplan-Meier curves to examine initiation of ADM after intestinal surgery and Cox regression to identify risk factors for ADM use after intestinal surgery. Results: We identified 1,272 cases of CD undergoing their first intestinal surgery. Of these, 871 (68.5%) had no stoma, 191 (15.0%) had a temporary stoma and 210 (16.5%) had a permanent stoma. The 10-year cumulative incidence of ADM use was 26.4%, 33.4% and 37.3% respectively. Individuals with a permanent stoma were 71% more likely to receive an ADM than those with no stoma (HR 1.71, 95% CI 1.20-2.44). Individuals with a temporary stoma reversed within 12 months had a similar likelihood of ADM use to those without stoma formation (HR 0.99, 95% CI 0.64-1.53) whereas temporary stoma formation with late reversal after 12 months was associated with significantly greater likelihood of ADM use (HR 1.85, 95% CI 1.15-2.96). Conclusions: Permanent stomas and temporary stomas with late reversal surgery are associated with increased ADM use after intestinal surgery, likely associated with increased anxiety and depression.",
keywords = "Antidepressants, Crohn's Disease, Psychosomatic Medicine, Stoma",
author = "Jonathan Blackwell and Sonia Saxena and Nishani Jayasooriya and Irene Petersen and Matthew Hotopf and Hanna Creese and Alex Bottle and Pollok, {Richard C.G.} and {POP-IBD Study Group}",
note = "Publisher Copyright: {\textcopyright} 2022 AGA Institute",
year = "2022",
month = apr,
doi = "10.1016/j.cgh.2020.12.026",
language = "English",
volume = "20",
pages = "e703--e710",
journal = "Clinical Gastroenterology and Hepatology",
issn = "1542-3565",
publisher = "W.B. Saunders Co.",
number = "4",

}

RIS

TY - JOUR

T1 - Stoma Formation in Crohn's Disease and the Likelihood of Antidepressant Use

T2 - A Population-Based Cohort Study

AU - Blackwell, Jonathan

AU - Saxena, Sonia

AU - Jayasooriya, Nishani

AU - Petersen, Irene

AU - Hotopf, Matthew

AU - Creese, Hanna

AU - Bottle, Alex

AU - Pollok, Richard C.G.

AU - POP-IBD Study Group

N1 - Publisher Copyright: © 2022 AGA Institute

PY - 2022/4

Y1 - 2022/4

N2 - Background & Aims: The impact of a temporary or permanent stoma on mental health in Crohn's Disease (CD) is unknown. The aim was to examine the association between intestinal surgery and stoma formation and subsequent antidepressant medication (ADM) use. Methods: Using the Clinical Practice Research Datalink, we identified individuals with CD who underwent intestinal surgery between 1998-2018. We excluded individuals with a prescription for an ADM in the 6 months before surgery. Individuals were stratified into three groups: no stoma, temporary stoma, and permanent stoma. We used Kaplan-Meier curves to examine initiation of ADM after intestinal surgery and Cox regression to identify risk factors for ADM use after intestinal surgery. Results: We identified 1,272 cases of CD undergoing their first intestinal surgery. Of these, 871 (68.5%) had no stoma, 191 (15.0%) had a temporary stoma and 210 (16.5%) had a permanent stoma. The 10-year cumulative incidence of ADM use was 26.4%, 33.4% and 37.3% respectively. Individuals with a permanent stoma were 71% more likely to receive an ADM than those with no stoma (HR 1.71, 95% CI 1.20-2.44). Individuals with a temporary stoma reversed within 12 months had a similar likelihood of ADM use to those without stoma formation (HR 0.99, 95% CI 0.64-1.53) whereas temporary stoma formation with late reversal after 12 months was associated with significantly greater likelihood of ADM use (HR 1.85, 95% CI 1.15-2.96). Conclusions: Permanent stomas and temporary stomas with late reversal surgery are associated with increased ADM use after intestinal surgery, likely associated with increased anxiety and depression.

AB - Background & Aims: The impact of a temporary or permanent stoma on mental health in Crohn's Disease (CD) is unknown. The aim was to examine the association between intestinal surgery and stoma formation and subsequent antidepressant medication (ADM) use. Methods: Using the Clinical Practice Research Datalink, we identified individuals with CD who underwent intestinal surgery between 1998-2018. We excluded individuals with a prescription for an ADM in the 6 months before surgery. Individuals were stratified into three groups: no stoma, temporary stoma, and permanent stoma. We used Kaplan-Meier curves to examine initiation of ADM after intestinal surgery and Cox regression to identify risk factors for ADM use after intestinal surgery. Results: We identified 1,272 cases of CD undergoing their first intestinal surgery. Of these, 871 (68.5%) had no stoma, 191 (15.0%) had a temporary stoma and 210 (16.5%) had a permanent stoma. The 10-year cumulative incidence of ADM use was 26.4%, 33.4% and 37.3% respectively. Individuals with a permanent stoma were 71% more likely to receive an ADM than those with no stoma (HR 1.71, 95% CI 1.20-2.44). Individuals with a temporary stoma reversed within 12 months had a similar likelihood of ADM use to those without stoma formation (HR 0.99, 95% CI 0.64-1.53) whereas temporary stoma formation with late reversal after 12 months was associated with significantly greater likelihood of ADM use (HR 1.85, 95% CI 1.15-2.96). Conclusions: Permanent stomas and temporary stomas with late reversal surgery are associated with increased ADM use after intestinal surgery, likely associated with increased anxiety and depression.

KW - Antidepressants

KW - Crohn's Disease

KW - Psychosomatic Medicine

KW - Stoma

UR - http://www.scopus.com/inward/record.url?scp=85111901679&partnerID=8YFLogxK

U2 - 10.1016/j.cgh.2020.12.026

DO - 10.1016/j.cgh.2020.12.026

M3 - Journal article

C2 - 33359727

AN - SCOPUS:85111901679

VL - 20

SP - e703-e710

JO - Clinical Gastroenterology and Hepatology

JF - Clinical Gastroenterology and Hepatology

SN - 1542-3565

IS - 4

ER -