Steepness of the dose-response curve as a function of volume in an experimental tumor irradiated under ambient or hypoxic conditions

Azza Ahmed Khalil, Søren M Bentzen, J Overgaard

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Abstract

Radiation dose-response curves play a fundamental role in the attempts to optimize radiotherapy, and it is a major task in clinical and experimental radiation research to characterize and quantify the factors that determine the position and shape of dose-response curves. A convenient measure of the steepness of radiation dose-response curves is the normalized dose-response gradient, gamma, which represents the increase in response, in percentage points, for a 1% increase in dose. Theoretically, the normalized dose-response gradient should increase with increasing clonogenic cell number or, assuming a constant clonogen density, with increasing tumor volume. The aim of this study was to test this hypothesis over a range of tumor volumes and to study how this relationship is affected by heterogeneity in tumor oxygenation.
Original languageEnglish
JournalInternational Journal of Radiation Oncology, Biology, Physics
Volume39
Issue4
Pages (from-to)797-802
Number of pages6
ISSN0360-3016
Publication statusPublished - 1 Nov 1997

Keywords

  • Animals
  • Cell Hypoxia
  • Dose-Response Relationship, Radiation
  • Female
  • Mammary Neoplasms, Experimental
  • Mice
  • Neoplasm Transplantation
  • Poisson Distribution

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