Standard procedures for the diagnostic pathway of sleep-related epilepsies and comorbid sleep disorders: an EAN, ESRS and ILAE-Europe consensus review

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

DOI

  • L Nobili, IRCCS G. Gaslini Institute, University of Genoa
  • ,
  • A de Weerd, Stichting Epilepsie Instellingen Nederland
  • ,
  • G Rubboli, Danish Epilepsy Centre, Dianaund, University of Copenhagen
  • ,
  • S Beniczky
  • C Derry, Western General Hospital, University of Edinburgh
  • ,
  • S Eriksson, University College London
  • ,
  • P Halasz, National Institute of Clinical Neurosciences
  • ,
  • B Högl, Univ Klin Innsbruck, Medical University of Innsbruck
  • ,
  • J Santamaria, Neurology Service and Multidisciplinary Sleep Disorders Unit, Hospital Clinic of Barcelona, Barcelona, Spain.
  • ,
  • R Khatami, University of Bern, Barmelweid Academy
  • ,
  • P Ryvlin, University of Lausanne
  • ,
  • J Rémi, Ludwig-Maximilians University
  • ,
  • P Tinuper, University of Bologna, Bologna, Italy., IRCCS Istituto delle Scienze Neurologiche di Bologna
  • ,
  • C Bassetti, University of Bern, Sechenov First Moscow State Medical University
  • ,
  • R Manni, IRCCS
  • ,
  • M Koutroumanidis, Guy's and St Thomas' NHS Foundation Trust
  • ,
  • L Vignatelli, IRCCS Istituto delle Scienze Neurologiche di Bologna

BACKGROUND AND PURPOSE: Some epilepsy syndromes (sleep-related epilepsies, SREs) have a strong link with sleep. Comorbid sleep disorders are common in patients with SRE and can exert a negative impact on seizure control and quality of life. Our purpose was to define the standard procedures for the diagnostic pathway of patients with possible SRE (scenario 1) and the general management of patients with SRE and comorbidity with sleep disorders (scenario 2).

METHODS: The project was conducted under the auspices of the European Academy of Neurology, the European Sleep Research Society and the International League Against Epilepsy Europe. The framework entailed the following phases: conception of the clinical scenarios; literature review; statements regarding the standard procedures. For the literature search a stepwise approach starting from systematic reviews to primary studies was applied. Published studies were identified from the National Library of Medicine's MEDLINE database and Cochrane Library.

RESULTS: Scenario 1: Despite a low quality of evidence, recommendations on anamnestic evaluation and tools for capturing the event at home or in the laboratory are provided for specific SREs. Scenario 2: Early diagnosis and treatment of sleep disorders (especially respiratory disorders) in patients with SRE are likely to be beneficial for seizure control.

CONCLUSIONS: Definitive procedures for evaluating patients with SRE are lacking. Advice is provided that could be of help for standardizing and improving the diagnostic approach of specific SREs. The importance of identifying and treating specific sleep disorders for the management and outcome of patients with SRE is underlined.

Original languageEnglish
JournalEuropean Journal of Neurology
Volume28
Issue1
Pages (from-to)15-32
Number of pages18
ISSN1351-5101
DOIs
Publication statusPublished - Jan 2021

    Research areas

  • clinical and diagnostic investigations, clinical neurophysiology, electroencephalography (EEG), epilepsy, guideline, insomnia, juvenile myoclonic epilepsy, neurological disorders, nocturnal seizures, panayiotopoulos syndrome, polysomnography, research methods, restless legs syndrome, rolandic epilepsy, seizure questionnaire, sleep-disordered breathing, sleep-related epilepsies, TONIC-CLONIC SEIZURES, FRONTAL-LOBE EPILEPSY, AIRWAY PRESSURE THERAPY, JUVENILE MYOCLONIC EPILEPSY, RESTLESS LEGS SYNDROME, CLINICAL-PRACTICE GUIDELINE, IDIOPATHIC GENERALIZED EPILEPSIES, HOME-VIDEO RECORDINGS, CHILDHOOD FOCAL EPILEPSIES, ELECTRICAL STATUS EPILEPTICUS

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