Stable analogues of nojirimycin--synthesis and biological evaluation of nojiristegine and manno-nojiristegine

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

DOI

  • Agnete H Viuff
  • ,
  • Louise M Besenbacher
  • ,
  • Akiko Kamori, Denmark
  • Mikkel T Jensen
  • ,
  • Mogens Kilian
  • Atsushi Kato
  • ,
  • Henrik H Jensen

Two novel iminosugars called nojiristegines, being structural hybrids between nor-tropane alkaloid calystegine and nojirimycins, have been synthesised and found to be stable molecules despite the presence of a hemiaminal functionality. The synthesised iminosugars were evaluated against a panel of glycosidases and the best inhibition (IC50), found against α-glucosidases, was in the micromolar region. The compounds were also evaluated as potential antibiotics but no useful level of activity was observed.

Original languageEnglish
JournalOrganic & Biomolecular Chemistry
Volume13
Issue37
Pages (from-to)9637-58
Number of pages22
ISSN1477-0520
DOIs
Publication statusPublished - 7 Oct 2015

See relations at Aarhus University Citationformats

ID: 95891635