Spotlight on the Ballet of Proteins: The Structural Dynamic Properties of Proteins Illuminated by Solution NMR

Yuji Tokunaga, Thibault Viennet, Haribabu Arthanari*, Koh Takeuchi*

*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

7 Citations (Scopus)

Abstract

Solution NMR spectroscopy is a unique and powerful technique that has the ability to directly connect the structural dynamics of proteins in physiological conditions to their activity and function. Here, we summarize recent studies in which solution NMR contributed to the discovery of relationships between key dynamic properties of proteins and functional mechanisms in important biological systems. The capacity of NMR to quantify the dynamics of proteins over a range of time scales and to detect lowly populated protein conformations plays a critical role in its power to unveil functional protein dynamics. This analysis of dynamics is not only important for the understanding of biological function, but also in the design of specific ligands for pharmacologically important proteins. Thus, the dynamic view of structure provided by NMR is of importance in both basic and applied biology.

Original languageEnglish
Article number1829
JournalInternational Journal of Molecular Sciences
Volume21
Issue5
Number of pages17
ISSN1661-6596
DOIs
Publication statusPublished - 1 Mar 2020
Externally publishedYes

Keywords

  • Conformational entropy
  • Drug development
  • Dynamics
  • Interaction
  • Protein function
  • Solution NMR

Fingerprint

Dive into the research topics of 'Spotlight on the Ballet of Proteins: The Structural Dynamic Properties of Proteins Illuminated by Solution NMR'. Together they form a unique fingerprint.

Cite this