Spinal cord stimulation in patients with painful diabetic neuropathy: a multicentre randomised clinical trial

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Spinal cord stimulation in patients with painful diabetic neuropathy: a multicentre randomised clinical trial. / de Vos, Cecile C; Meier, Kaare; Zaalberg, Paul Brocades; Nijhuis, Harold J A; Duyvendak, Wim; Vesper, Jan; Enggaard, Thomas P; Lenders, Mathieu W P M.

In: Pain, Vol. 155, No. 11, 2014, p. 2426-2431.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

de Vos, CC, Meier, K, Zaalberg, PB, Nijhuis, HJA, Duyvendak, W, Vesper, J, Enggaard, TP & Lenders, MWPM 2014, 'Spinal cord stimulation in patients with painful diabetic neuropathy: a multicentre randomised clinical trial', Pain, vol. 155, no. 11, pp. 2426-2431. https://doi.org/10.1016/j.pain.2014.08.031

APA

de Vos, C. C., Meier, K., Zaalberg, P. B., Nijhuis, H. J. A., Duyvendak, W., Vesper, J., Enggaard, T. P., & Lenders, M. W. P. M. (2014). Spinal cord stimulation in patients with painful diabetic neuropathy: a multicentre randomised clinical trial. Pain, 155(11), 2426-2431. https://doi.org/10.1016/j.pain.2014.08.031

CBE

de Vos CC, Meier K, Zaalberg PB, Nijhuis HJA, Duyvendak W, Vesper J, Enggaard TP, Lenders MWPM. 2014. Spinal cord stimulation in patients with painful diabetic neuropathy: a multicentre randomised clinical trial. Pain. 155(11):2426-2431. https://doi.org/10.1016/j.pain.2014.08.031

MLA

Vancouver

Author

de Vos, Cecile C ; Meier, Kaare ; Zaalberg, Paul Brocades ; Nijhuis, Harold J A ; Duyvendak, Wim ; Vesper, Jan ; Enggaard, Thomas P ; Lenders, Mathieu W P M. / Spinal cord stimulation in patients with painful diabetic neuropathy: a multicentre randomised clinical trial. In: Pain. 2014 ; Vol. 155, No. 11. pp. 2426-2431.

Bibtex

@article{fc6e574835dc4bc58b450bf6b71aa9ab,
title = "Spinal cord stimulation in patients with painful diabetic neuropathy: a multicentre randomised clinical trial",
abstract = "Painful diabetic neuropathy (PDN) is a peripheral neuropathic pain condition that is often very difficult to relieve. Spinal Cord Stimulation (SCS) is a proven effective therapy for various types of mixed neuropathic conditions, yet effectiveness of SCS treatment for PDN is not well established. This is the first multicentre randomised controlled trial investigating the effectiveness of SCS in patients with PDN. Sixty patients with PDN in the lower extremities, refractory to conventional medical therapy, were enrolled and followed for six months. They were randomised 2:1 to best conventional medical practice with (SCS group) or without (control group) additional SCS therapy and both groups were followed up at regular intervals. At each follow-up visit, the EuroQoL 5D, the short form McGill Pain Questionnaire (SF-MPQ) and a visual analogue scale (VAS, ranging from 0-100) to measure pain intensity were recorded. The average VAS score for pain intensity was 73 in the SCS group and 67 in the control group at baseline. After six months of treatment the average VAS score was significantly reduced to 31 in the SCS group (p<0.001) and remained 67 (p=0.97) in the control group. The SF-MPQ and EuroQoL 5D questionnaires also showed that patients in the SCS group, unlike those in the control group, experienced reduced pain and improved health and quality of life after six months of treatment. In patients with refractory painful diabetic neuropathy, spinal cord stimulation therapy significantly reduces pain and improves quality of life.",
author = "{de Vos}, {Cecile C} and Kaare Meier and Zaalberg, {Paul Brocades} and Nijhuis, {Harold J A} and Wim Duyvendak and Jan Vesper and Enggaard, {Thomas P} and Lenders, {Mathieu W P M}",
note = "Epub 29 Aug 2014",
year = "2014",
doi = "10.1016/j.pain.2014.08.031",
language = "English",
volume = "155",
pages = "2426--2431",
journal = "Pain",
issn = "0304-3959",
publisher = "IASP Press",
number = "11",

}

RIS

TY - JOUR

T1 - Spinal cord stimulation in patients with painful diabetic neuropathy: a multicentre randomised clinical trial

AU - de Vos, Cecile C

AU - Meier, Kaare

AU - Zaalberg, Paul Brocades

AU - Nijhuis, Harold J A

AU - Duyvendak, Wim

AU - Vesper, Jan

AU - Enggaard, Thomas P

AU - Lenders, Mathieu W P M

N1 - Epub 29 Aug 2014

PY - 2014

Y1 - 2014

N2 - Painful diabetic neuropathy (PDN) is a peripheral neuropathic pain condition that is often very difficult to relieve. Spinal Cord Stimulation (SCS) is a proven effective therapy for various types of mixed neuropathic conditions, yet effectiveness of SCS treatment for PDN is not well established. This is the first multicentre randomised controlled trial investigating the effectiveness of SCS in patients with PDN. Sixty patients with PDN in the lower extremities, refractory to conventional medical therapy, were enrolled and followed for six months. They were randomised 2:1 to best conventional medical practice with (SCS group) or without (control group) additional SCS therapy and both groups were followed up at regular intervals. At each follow-up visit, the EuroQoL 5D, the short form McGill Pain Questionnaire (SF-MPQ) and a visual analogue scale (VAS, ranging from 0-100) to measure pain intensity were recorded. The average VAS score for pain intensity was 73 in the SCS group and 67 in the control group at baseline. After six months of treatment the average VAS score was significantly reduced to 31 in the SCS group (p<0.001) and remained 67 (p=0.97) in the control group. The SF-MPQ and EuroQoL 5D questionnaires also showed that patients in the SCS group, unlike those in the control group, experienced reduced pain and improved health and quality of life after six months of treatment. In patients with refractory painful diabetic neuropathy, spinal cord stimulation therapy significantly reduces pain and improves quality of life.

AB - Painful diabetic neuropathy (PDN) is a peripheral neuropathic pain condition that is often very difficult to relieve. Spinal Cord Stimulation (SCS) is a proven effective therapy for various types of mixed neuropathic conditions, yet effectiveness of SCS treatment for PDN is not well established. This is the first multicentre randomised controlled trial investigating the effectiveness of SCS in patients with PDN. Sixty patients with PDN in the lower extremities, refractory to conventional medical therapy, were enrolled and followed for six months. They were randomised 2:1 to best conventional medical practice with (SCS group) or without (control group) additional SCS therapy and both groups were followed up at regular intervals. At each follow-up visit, the EuroQoL 5D, the short form McGill Pain Questionnaire (SF-MPQ) and a visual analogue scale (VAS, ranging from 0-100) to measure pain intensity were recorded. The average VAS score for pain intensity was 73 in the SCS group and 67 in the control group at baseline. After six months of treatment the average VAS score was significantly reduced to 31 in the SCS group (p<0.001) and remained 67 (p=0.97) in the control group. The SF-MPQ and EuroQoL 5D questionnaires also showed that patients in the SCS group, unlike those in the control group, experienced reduced pain and improved health and quality of life after six months of treatment. In patients with refractory painful diabetic neuropathy, spinal cord stimulation therapy significantly reduces pain and improves quality of life.

U2 - 10.1016/j.pain.2014.08.031

DO - 10.1016/j.pain.2014.08.031

M3 - Journal article

C2 - 25180016

VL - 155

SP - 2426

EP - 2431

JO - Pain

JF - Pain

SN - 0304-3959

IS - 11

ER -