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Specific incorporation of kinetin into eukaryotic and prokaryotic transfer ribonucleic acid molecules

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We show that kinetin, a non-natural product with strong cytokinin activity, is incorporated into prokaryotic and eukaryotic tRNAs in the exchange reaction catalysed by a putative tRNA-kinetin transglycosylase. We also show that kinetin is specifically incorporated into E. coli tRNA(Tyr) and most probably at position 37. To our knowledge, this is the first report of a nucleic acid base exchange reaction occurring at this position.

Original languageEnglish
JournalBiochemistry international
Pages (from-to)805-811
Number of pages7
Publication statusPublished - 1 Dec 1992

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