Specific Contamination Symptoms are Associated with Experiencing a Limited Response of Cognitive-Behavioral Therapy in Pediatric Patients with OCD

Charlotte Steen Duholm; Sanne Jensen; Charlotte Ulrikka Rask; Per Hove Thomsen; Tord Ivarsson; Gudmundur Skarphedinsson; Nor Christian Torp; Bernhard Weidle; Judith Becker Nissen; Davíð R.M.A. Højgaard

doi:10.1007/s10578-022-01480-y

Specific Contamination Symptoms are Associated with Experiencing a Limited Response of Cognitive-Behavioral Therapy in Pediatric Patients with OCD

Charlotte Steen Duholm^*, Sanne Jensen, Charlotte Ulrikka Rask, Per Hove Thomsen, Tord Ivarsson, Gudmundur Skarphedinsson, Nor Christian Torp, Bernhard Weidle, Judith Becker Nissen, Davíð R.M.A. Højgaard

^*Corresponding author for this work

Department of Clinical Medicine - Psychiatric Hospital for Children and Adolescents

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Abstract

A recent study identified three distinct treatment-response trajectories in pediatric OCD where higher levels of contamination symptoms predicted a limited response to cognitive-behavioral therapy (CBT). This study extends these findings by examining which specific symptoms characterize limited CBT response from baseline to 3-year follow-up, with an emphasis on contamination symptoms. The study sample comprised 269 pediatric patients with OCD, all receiving stepped-care treatment with manualized CBT. Differences in single item-reporting between the three trajectory groups were examined using linear mixed-effect modeling. Limited responders displayed a higher symptom load across all OCD symptom categories at 3-year follow-up, dominated by contamination symptoms. Five of these (obsessions about dirt and germs, about bodily fluids, about the feeling of contamination and compulsions regarding handwashing and showering) showed persistence from baseline to 3-year follow-up. The results indicate that presence of specific contamination symptoms may influence long-term symptom severity trajectories in young patients with OCD.

Original language	English
Journal	Child Psychiatry and Human Development
Volume	55
Issue	4
Pages (from-to)	1135-1145
Number of pages	11
ISSN	0009-398X
DOIs	https://doi.org/10.1007/s10578-022-01480-y
Publication status	Published - Aug 2024

Keywords

Children and adolescents
Cognitive-behavioral therapy
Longitudinal study
Obsessive–compulsive disorder
Obsessive–compulsive symptoms

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10.1007/s10578-022-01480-y

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Duholm, C. S., Jensen, S., Rask, C. U., Thomsen, P. H., Ivarsson, T., Skarphedinsson, G., Torp, N. C., Weidle, B., Nissen, J. B., & Højgaard, D. R. M. A. (2024). Specific Contamination Symptoms are Associated with Experiencing a Limited Response of Cognitive-Behavioral Therapy in Pediatric Patients with OCD. Child Psychiatry and Human Development, 55(4), 1135-1145. https://doi.org/10.1007/s10578-022-01480-y

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title = "Specific Contamination Symptoms are Associated with Experiencing a Limited Response of Cognitive-Behavioral Therapy in Pediatric Patients with OCD",

abstract = "A recent study identified three distinct treatment-response trajectories in pediatric OCD where higher levels of contamination symptoms predicted a limited response to cognitive-behavioral therapy (CBT). This study extends these findings by examining which specific symptoms characterize limited CBT response from baseline to 3-year follow-up, with an emphasis on contamination symptoms. The study sample comprised 269 pediatric patients with OCD, all receiving stepped-care treatment with manualized CBT. Differences in single item-reporting between the three trajectory groups were examined using linear mixed-effect modeling. Limited responders displayed a higher symptom load across all OCD symptom categories at 3-year follow-up, dominated by contamination symptoms. Five of these (obsessions about dirt and germs, about bodily fluids, about the feeling of contamination and compulsions regarding handwashing and showering) showed persistence from baseline to 3-year follow-up. The results indicate that presence of specific contamination symptoms may influence long-term symptom severity trajectories in young patients with OCD.",

keywords = "Children and adolescents, Cognitive-behavioral therapy, Longitudinal study, Obsessive–compulsive disorder, Obsessive–compulsive symptoms",

author = "Duholm, {Charlotte Steen} and Sanne Jensen and Rask, {Charlotte Ulrikka} and Thomsen, {Per Hove} and Tord Ivarsson and Gudmundur Skarphedinsson and Torp, {Nor Christian} and Bernhard Weidle and Nissen, {Judith Becker} and H{\o}jgaard, {Dav{\'i}{\dh} R.M.A.}",

note = "Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.",

year = "2024",

month = aug,

doi = "10.1007/s10578-022-01480-y",

language = "English",

volume = "55",

pages = "1135--1145",

journal = "Child Psychiatry and Human Development",

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Duholm, CS , Jensen, S , Rask, CU , Thomsen, PH, Ivarsson, T, Skarphedinsson, G, Torp, NC, Weidle, B, Nissen, JB & Højgaard, DRMA 2024, 'Specific Contamination Symptoms are Associated with Experiencing a Limited Response of Cognitive-Behavioral Therapy in Pediatric Patients with OCD', Child Psychiatry and Human Development, vol. 55, no. 4, pp. 1135-1145. https://doi.org/10.1007/s10578-022-01480-y

Specific Contamination Symptoms are Associated with Experiencing a Limited Response of Cognitive-Behavioral Therapy in Pediatric Patients with OCD. / Duholm, Charlotte Steen ; Jensen, Sanne ; Rask, Charlotte Ulrikka et al.
In: Child Psychiatry and Human Development, Vol. 55, No. 4, 08.2024, p. 1135-1145.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

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T1 - Specific Contamination Symptoms are Associated with Experiencing a Limited Response of Cognitive-Behavioral Therapy in Pediatric Patients with OCD

AU - Duholm, Charlotte Steen

AU - Jensen, Sanne

AU - Rask, Charlotte Ulrikka

AU - Thomsen, Per Hove

AU - Ivarsson, Tord

AU - Skarphedinsson, Gudmundur

AU - Torp, Nor Christian

AU - Weidle, Bernhard

AU - Nissen, Judith Becker

AU - Højgaard, Davíð R.M.A.

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N2 - A recent study identified three distinct treatment-response trajectories in pediatric OCD where higher levels of contamination symptoms predicted a limited response to cognitive-behavioral therapy (CBT). This study extends these findings by examining which specific symptoms characterize limited CBT response from baseline to 3-year follow-up, with an emphasis on contamination symptoms. The study sample comprised 269 pediatric patients with OCD, all receiving stepped-care treatment with manualized CBT. Differences in single item-reporting between the three trajectory groups were examined using linear mixed-effect modeling. Limited responders displayed a higher symptom load across all OCD symptom categories at 3-year follow-up, dominated by contamination symptoms. Five of these (obsessions about dirt and germs, about bodily fluids, about the feeling of contamination and compulsions regarding handwashing and showering) showed persistence from baseline to 3-year follow-up. The results indicate that presence of specific contamination symptoms may influence long-term symptom severity trajectories in young patients with OCD.

AB - A recent study identified three distinct treatment-response trajectories in pediatric OCD where higher levels of contamination symptoms predicted a limited response to cognitive-behavioral therapy (CBT). This study extends these findings by examining which specific symptoms characterize limited CBT response from baseline to 3-year follow-up, with an emphasis on contamination symptoms. The study sample comprised 269 pediatric patients with OCD, all receiving stepped-care treatment with manualized CBT. Differences in single item-reporting between the three trajectory groups were examined using linear mixed-effect modeling. Limited responders displayed a higher symptom load across all OCD symptom categories at 3-year follow-up, dominated by contamination symptoms. Five of these (obsessions about dirt and germs, about bodily fluids, about the feeling of contamination and compulsions regarding handwashing and showering) showed persistence from baseline to 3-year follow-up. The results indicate that presence of specific contamination symptoms may influence long-term symptom severity trajectories in young patients with OCD.

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JO - Child Psychiatry and Human Development

JF - Child Psychiatry and Human Development

IS - 4

ER -

Specific Contamination Symptoms are Associated with Experiencing a Limited Response of Cognitive-Behavioral Therapy in Pediatric Patients with OCD

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