TY - JOUR
T1 - Spatiotemporal whole-brain activity and functional connectivity of melodies recognition
AU - Bonetti, Leonardo
AU - Brattico, Elvira
AU - Carlomagno, Francesco
AU - Cabral, Joana
AU - Stevner, Angus
AU - Deco, Gustavo
AU - Whybrow, Peter C.
AU - Pearce, Marcus
AU - Pantazis, Dimitrios
AU - Vuust, Peter
AU - Kringelbach, Morten L.
N1 - Publisher Copyright:
© The Author(s) 2024.
PY - 2024/8/1
Y1 - 2024/8/1
N2 - Music is a non-verbal human language, built on logical, hierarchical structures, that offers excellent opportunities to explore how the brain processes complex spatiotemporal auditory sequences. Using the high temporal resolution of magnetoencephalography, we investigated the unfolding brain dynamics of 70 participants during the recognition of previously memorized musical sequences compared to novel sequences matched in terms of entropy and information content. Measures of both whole-brain activity and functional connectivity revealed a widespread brain network underlying the recognition of the memorized auditory sequences, which comprised primary auditory cortex, superior temporal gyrus, insula, frontal operculum, cingulate gyrus, orbitofrontal cortex, basal ganglia, thalamus, and hippocampus. Furthermore, while the auditory cortex responded mainly to the first tones of the sequences, the activity of higher-order brain areas such as the cingulate gyrus, frontal operculum, hippocampus, and orbitofrontal cortex largely increased over time during the recognition of the memorized versus novel musical sequences. In conclusion, using a wide range of analytical techniques spanning from decoding to functional connectivity and building on previous works, our study provided new insights into the spatiotemporal whole-brain mechanisms for conscious recognition of auditory sequences.
AB - Music is a non-verbal human language, built on logical, hierarchical structures, that offers excellent opportunities to explore how the brain processes complex spatiotemporal auditory sequences. Using the high temporal resolution of magnetoencephalography, we investigated the unfolding brain dynamics of 70 participants during the recognition of previously memorized musical sequences compared to novel sequences matched in terms of entropy and information content. Measures of both whole-brain activity and functional connectivity revealed a widespread brain network underlying the recognition of the memorized auditory sequences, which comprised primary auditory cortex, superior temporal gyrus, insula, frontal operculum, cingulate gyrus, orbitofrontal cortex, basal ganglia, thalamus, and hippocampus. Furthermore, while the auditory cortex responded mainly to the first tones of the sequences, the activity of higher-order brain areas such as the cingulate gyrus, frontal operculum, hippocampus, and orbitofrontal cortex largely increased over time during the recognition of the memorized versus novel musical sequences. In conclusion, using a wide range of analytical techniques spanning from decoding to functional connectivity and building on previous works, our study provided new insights into the spatiotemporal whole-brain mechanisms for conscious recognition of auditory sequences.
KW - brain spatiotemporal dynamics
KW - functional connectivity
KW - magnetoencephalography (MEG)
KW - memory
KW - sequence recognition
UR - http://www.scopus.com/inward/record.url?scp=85200993388&partnerID=8YFLogxK
U2 - 10.1093/cercor/bhae320
DO - 10.1093/cercor/bhae320
M3 - Journal article
C2 - 39110413
AN - SCOPUS:85200993388
SN - 1047-3211
VL - 34
JO - Cerebral Cortex
JF - Cerebral Cortex
IS - 8
M1 - e320
ER -