Spatio-temporal regulation of ADAR editing during development in porcine neural tissues

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  • Morten Trillingsgaard Venø, Denmark
  • Jesper Bertram Bramsen
  • Christian Bendixen, Denmark
  • Frank Panitz
  • Ida Elisabeth Holm, Laboratory for Experimental Neuropathology, Department of Pathology, Randers Hospital, Denmark
  • Marie Öhman, Department of Molecular Biology and Functional Genomics; Stockholm University, Sweden
  • Jørgen Kjems
Editing by ADAR enzymes is essential for mammalian life. Still, knowledge of the spatio-temporal editing patterns in mammals is limited. By use of 454 amplicon sequencing we examined the editing status of 12 regionally extracted mRNAs from porcine developing brain encompassing a total of 64 putative ADAR editing sites. In total 24 brain tissues, dissected from up to five regions from embryonic gestation day 23, 42, 60, 80, 100 and 115, were examined for editing.
Original languageEnglish
JournalRNA Biology
Pages (from-to)1054-1065
Number of pages12
Publication statusPublished - Aug 2012

    Research areas

  • ADAR2, ADAR, Blcap, Pig, Htt2c, 5-HT2C receptor, RNA editing, Gria2, GluR-B

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