Spatio-temporal regulation of ADAR editing during development in porcine neural tissues

Morten Trillingsgaard Venø; Jesper Bertram Bramsen; Christian Bendixen; Frank Panitz; Ida Elisabeth Holm; Marie Öhman; Jørgen Kjems

doi:10.4161/rna.21082

Spatio-temporal regulation of ADAR editing during development in porcine neural tissues

Morten Trillingsgaard Venø, Jesper Bertram Bramsen, Christian Bendixen, Frank Panitz, Ida Elisabeth Holm, Marie Öhman, Jørgen Kjems

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

34 Citations (Scopus)

Abstract

Editing by ADAR enzymes is essential for mammalian life. Still, knowledge of the spatio-temporal editing patterns in mammals is limited. By use of 454 amplicon sequencing we examined the editing status of 12 regionally extracted mRNAs from porcine developing brain encompassing a total of 64 putative ADAR editing sites. In total 24 brain tissues, dissected from up to five regions from embryonic gestation day 23, 42, 60, 80, 100 and 115, were examined for editing.

Original language	English
Journal	RNA Biology
Volume	9
Issue	8
Pages (from-to)	1054-1065
Number of pages	12
ISSN	1547-6286
DOIs	https://doi.org/10.4161/rna.21082
Publication status	Published - Aug 2012

Keywords

ADAR2
ADAR
Blcap
Pig
Htt2c
5-HT2C receptor
RNA editing
Gria2
GluR-B

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title = "Spatio-temporal regulation of ADAR editing during development in porcine neural tissues",

abstract = "Editing by ADAR enzymes is essential for mammalian life. Still, knowledge of the spatio-temporal editing patterns in mammals is limited. By use of 454 amplicon sequencing we examined the editing status of 12 regionally extracted mRNAs from porcine developing brain encompassing a total of 64 putative ADAR editing sites. In total 24 brain tissues, dissected from up to five regions from embryonic gestation day 23, 42, 60, 80, 100 and 115, were examined for editing. ",

keywords = "ADAR2, ADAR, Blcap, Pig, Htt2c, 5-HT2C receptor, RNA editing, Gria2, GluR-B",

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year = "2012",

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doi = "10.4161/rna.21082",

language = "English",

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Spatio-temporal regulation of ADAR editing during development in porcine neural tissues. / Venø, Morten Trillingsgaard; Bramsen, Jesper Bertram; Bendixen, Christian et al.
In: RNA Biology, Vol. 9, No. 8, 08.2012, p. 1054-1065.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

TY - JOUR

T1 - Spatio-temporal regulation of ADAR editing during development in porcine neural tissues

AU - Venø, Morten Trillingsgaard

AU - Bramsen, Jesper Bertram

AU - Bendixen, Christian

AU - Panitz, Frank

AU - Holm, Ida Elisabeth

AU - Öhman, Marie

AU - Kjems, Jørgen

PY - 2012/8

Y1 - 2012/8

N2 - Editing by ADAR enzymes is essential for mammalian life. Still, knowledge of the spatio-temporal editing patterns in mammals is limited. By use of 454 amplicon sequencing we examined the editing status of 12 regionally extracted mRNAs from porcine developing brain encompassing a total of 64 putative ADAR editing sites. In total 24 brain tissues, dissected from up to five regions from embryonic gestation day 23, 42, 60, 80, 100 and 115, were examined for editing.

AB - Editing by ADAR enzymes is essential for mammalian life. Still, knowledge of the spatio-temporal editing patterns in mammals is limited. By use of 454 amplicon sequencing we examined the editing status of 12 regionally extracted mRNAs from porcine developing brain encompassing a total of 64 putative ADAR editing sites. In total 24 brain tissues, dissected from up to five regions from embryonic gestation day 23, 42, 60, 80, 100 and 115, were examined for editing.

KW - ADAR2

KW - ADAR

KW - Blcap

KW - Pig

KW - Htt2c

KW - 5-HT2C receptor

KW - RNA editing

KW - Gria2

KW - GluR-B

U2 - 10.4161/rna.21082

DO - 10.4161/rna.21082

M3 - Journal article

C2 - 22858680

SN - 1547-6286

VL - 9

SP - 1054

EP - 1065

JO - RNA Biology

JF - RNA Biology

IS - 8

ER -

Spatio-temporal regulation of ADAR editing during development in porcine neural tissues

Abstract

Keywords

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