TY - JOUR
T1 - Spatially engineering tri-layer nanofiber dressings featuring asymmetric wettability for wound healing
AU - Shi, Tingting
AU - Liu, Yuan
AU - Wang, Donghui
AU - Xia, Dan
AU - Li, Baoe
AU - Xu, Ruodan
AU - Li, Ning
AU - Liang, Chunyong
AU - Chen, Menglin
N1 - Publisher Copyright:
© 2024 Chongqing University
PY - 2024/10
Y1 - 2024/10
N2 - Inspired by the skin structure, an asymmetric wettability tri-layer nanofiber membrane (TNM) consisting of hydrophilic inner layer loaded with lidocaine hydrochloride (LID), hydrophobic middle layer with ciprofloxacin (CIP) and hydrophobic outer layer has been created. The hydrophobic outer layer endows the TNM with waterproof function and anti-adhesion from contaminants. The hydrophobic middle layer with CIP preserves long-term inhibition of bacteria growth and the hydrophilic inner layer with LID possesses optimal water-absorbing capacity and air permeability. The TNM dramatically elevates the water contact angles from 10° (inner layer) to 120° (outer layer), indicating an asymmetric wettability, which could directionally transport wound exudate within the materials and meanwhile maintain a comfortable and moist environment to promote wound healing. Furthermore, the sequential release of LID and CIP could relieve pain rapidly and achieve antibacterial effect in the long run, respectively. In addition, the TNM shows superior biocompatibility towards L929 cells. The in vivo results show the TNM could prevent infection, accelerate epithelial regeneration and significantly accelerate wound healing. This study indicates the developed TNM with asymmetrical wettability and synergetic drug release shows great potential as a wound dressing in clinical application.
AB - Inspired by the skin structure, an asymmetric wettability tri-layer nanofiber membrane (TNM) consisting of hydrophilic inner layer loaded with lidocaine hydrochloride (LID), hydrophobic middle layer with ciprofloxacin (CIP) and hydrophobic outer layer has been created. The hydrophobic outer layer endows the TNM with waterproof function and anti-adhesion from contaminants. The hydrophobic middle layer with CIP preserves long-term inhibition of bacteria growth and the hydrophilic inner layer with LID possesses optimal water-absorbing capacity and air permeability. The TNM dramatically elevates the water contact angles from 10° (inner layer) to 120° (outer layer), indicating an asymmetric wettability, which could directionally transport wound exudate within the materials and meanwhile maintain a comfortable and moist environment to promote wound healing. Furthermore, the sequential release of LID and CIP could relieve pain rapidly and achieve antibacterial effect in the long run, respectively. In addition, the TNM shows superior biocompatibility towards L929 cells. The in vivo results show the TNM could prevent infection, accelerate epithelial regeneration and significantly accelerate wound healing. This study indicates the developed TNM with asymmetrical wettability and synergetic drug release shows great potential as a wound dressing in clinical application.
KW - Asymmetric wettability
KW - Biofunctional wound dressing
KW - Electrospinning
KW - Tri-layer nanofibrous membrane
UR - https://www.scopus.com/pages/publications/85183871504
U2 - 10.1016/j.nanoms.2024.01.008
DO - 10.1016/j.nanoms.2024.01.008
M3 - Journal article
AN - SCOPUS:85183871504
SN - 2096-6482
VL - 6
SP - 611
EP - 624
JO - Nano Materials Science
JF - Nano Materials Science
IS - 5
ER -