Spatial Mapping and Quantification of Soft and Hard Protein Coronas at Silver Nanocubes

Teodora Miclaus, Vladimir Bochenkov, Ryosuke Ogaki, Ken Howard, Duncan S Sutherland

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Abstract

Protein coronas around silver nanocubes were quantified in serum-containing media using localized surface plasmon resonances. Both soft and hard coronas showed exposure-time and concentration-dependent changes in protein surface density with time-dependent hardening. We observed spatially dependent kinetics of the corona-formation at cube edges/corners versus facets at short incubation times, where the polymer stabilization agent delayed corona hardening. The soft corona contained more protein than the hard corona at all time-points (8-fold difference with 10% serum conditions).
Original languageEnglish
JournalNano Letters
Volume14
Issue4
Pages (from-to)2086-2093
Number of pages8
ISSN1530-6984
DOIs
Publication statusPublished - 11 Mar 2014

Keywords

  • Silver nanocubes
  • soft corona
  • hard corona
  • localized surface plasmon resonance
  • protein corona quantification

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