Space balls revisited: Stereological estimates of length with virtual isotropic surface probes

Mark J. West*

*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Abstract

The space ball probe was fully described in the literature 15 years ago by Mouton et al. (2002). Since then, it has been used in a number of studies in the nervous system that focus on axon, dendrite, and capillary length. The length of structural parameters in tissues reflect functional aspects of the tissues. Here, some of the various applications of this methodology will be presented, along with a review of the salient features of the methodology that has resulted in new wave of quantitative morphological studies of length in the nervous system. The validity of the method is discussed in view of its widespread use along with insights into the problems associated with its application to histological tissue and future techniques for applying space balls.

Original languageEnglish
Article number49
JournalFrontiers in Neuroanatomy
Volume12
ISSN1662-5129
DOIs
Publication statusPublished - 12 Jun 2018

Keywords

  • Isotropic probe
  • Length
  • Space ball
  • Stereology
  • Unbiased

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