Sortilin in microglia reactivity: Investigating the mechanism underlying the impairment of neuropathic pain in sortilin knockout mice

Anne Louise Søby Svenningsen; Sara Buskbjerg Jager; Mette Richner; Ruthe Dieu; Lone Tjener Pallesen; Christian Bjerggaard Vægter

Sortilin in microglia reactivity: Investigating the mechanism underlying the impairment of neuropathic pain in sortilin knockout mice

Anne Louise Søby Svenningsen, Sara Buskbjerg Jager, Mette Richner, Ruthe Dieu, Lone Tjener Pallesen, Christian Bjerggaard Vægter

Research output: Contribution to conference › Conference abstract for conference › Research

Abstract

Neuropathic pain is a serious neurological disease affecting patients with peripheral nerve injuries and neuropathies. Unfortunately, the existing treatments are insufficient in giving patients pain relieve and preventing the development of neuropathic pain.

Neuroinflammation is a major contributing factor in the development of neuropathic pain. It has been well accepted that activation of microglia is essential in the spinal neuroinflammatory process underlying development of neuropathic pain after peripheral nerve injury. Unpublished data from sortilin knockout mice shows that the lack of the neuronal receptor, Sortilin, decreases development of neuropathic pain after peripheral nerve injury. Because Sortilin influences the inflammatory response in macrophages, it may also affect the response in microglia and the spinal neuroinflammation. Therefore, the aim of this project is to understand how Sortilin influences the spinal microglial response following peripheral nerve injury.

We plan to investigate cultures of spinal microglia from wild type and Sortilin knockout mice by comparing the cytokine profiles in culture medium, gene expression and intracellular protein levels of cytokines. Understanding the response in microglia might contribute to the knowledge of neuroinflammatory diseases in general and hopefully prove Sortilin as a potential drug target in the development of future treatments for neuropathic pain.

Original language	English
Publication date	2 Jul 2016
Publication status	Published - 2 Jul 2016
Event	10th FENS Forum of Neuroscience - København, Denmark Duration: 2 Jul 2016 → 6 Jul 2016

Conference

Conference	10th FENS Forum of Neuroscience
Country/Territory	Denmark
City	København
Period	02/07/2016 → 06/07/2016

Cite this

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title = "Sortilin in microglia reactivity: Investigating the mechanism underlying the impairment of neuropathic pain in sortilin knockout mice",

abstract = "Neuropathic pain is a serious neurological disease affecting patients with peripheral nerve injuries and neuropathies. Unfortunately, the existing treatments are insufficient in giving patients pain relieve and preventing the development of neuropathic pain.Neuroinflammation is a major contributing factor in the development of neuropathic pain. It has been well accepted that activation of microglia is essential in the spinal neuroinflammatory process underlying development of neuropathic pain after peripheral nerve injury. Unpublished data from sortilin knockout mice shows that the lack of the neuronal receptor, Sortilin, decreases development of neuropathic pain after peripheral nerve injury. Because Sortilin influences the inflammatory response in macrophages, it may also affect the response in microglia and the spinal neuroinflammation. Therefore, the aim of this project is to understand how Sortilin influences the spinal microglial response following peripheral nerve injury.We plan to investigate cultures of spinal microglia from wild type and Sortilin knockout mice by comparing the cytokine profiles in culture medium, gene expression and intracellular protein levels of cytokines. Understanding the response in microglia might contribute to the knowledge of neuroinflammatory diseases in general and hopefully prove Sortilin as a potential drug target in the development of future treatments for neuropathic pain.",

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language = "English",

note = "10th FENS Forum of Neuroscience ; Conference date: 02-07-2016 Through 06-07-2016",

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Sortilin in microglia reactivity: Investigating the mechanism underlying the impairment of neuropathic pain in sortilin knockout mice. / Svenningsen, Anne Louise Søby; Jager, Sara Buskbjerg; Richner, Mette et al.
2016. Abstract from 10th FENS Forum of Neuroscience, København, Denmark.

Research output: Contribution to conference › Conference abstract for conference › Research

TY - ABST

T1 - Sortilin in microglia reactivity

T2 - 10th FENS Forum of Neuroscience

AU - Svenningsen, Anne Louise Søby

AU - Jager, Sara Buskbjerg

AU - Richner, Mette

AU - Dieu, Ruthe

AU - Pallesen, Lone Tjener

AU - Vægter, Christian Bjerggaard

PY - 2016/7/2

Y1 - 2016/7/2

N2 - Neuropathic pain is a serious neurological disease affecting patients with peripheral nerve injuries and neuropathies. Unfortunately, the existing treatments are insufficient in giving patients pain relieve and preventing the development of neuropathic pain.Neuroinflammation is a major contributing factor in the development of neuropathic pain. It has been well accepted that activation of microglia is essential in the spinal neuroinflammatory process underlying development of neuropathic pain after peripheral nerve injury. Unpublished data from sortilin knockout mice shows that the lack of the neuronal receptor, Sortilin, decreases development of neuropathic pain after peripheral nerve injury. Because Sortilin influences the inflammatory response in macrophages, it may also affect the response in microglia and the spinal neuroinflammation. Therefore, the aim of this project is to understand how Sortilin influences the spinal microglial response following peripheral nerve injury.We plan to investigate cultures of spinal microglia from wild type and Sortilin knockout mice by comparing the cytokine profiles in culture medium, gene expression and intracellular protein levels of cytokines. Understanding the response in microglia might contribute to the knowledge of neuroinflammatory diseases in general and hopefully prove Sortilin as a potential drug target in the development of future treatments for neuropathic pain.

AB - Neuropathic pain is a serious neurological disease affecting patients with peripheral nerve injuries and neuropathies. Unfortunately, the existing treatments are insufficient in giving patients pain relieve and preventing the development of neuropathic pain.Neuroinflammation is a major contributing factor in the development of neuropathic pain. It has been well accepted that activation of microglia is essential in the spinal neuroinflammatory process underlying development of neuropathic pain after peripheral nerve injury. Unpublished data from sortilin knockout mice shows that the lack of the neuronal receptor, Sortilin, decreases development of neuropathic pain after peripheral nerve injury. Because Sortilin influences the inflammatory response in macrophages, it may also affect the response in microglia and the spinal neuroinflammation. Therefore, the aim of this project is to understand how Sortilin influences the spinal microglial response following peripheral nerve injury.We plan to investigate cultures of spinal microglia from wild type and Sortilin knockout mice by comparing the cytokine profiles in culture medium, gene expression and intracellular protein levels of cytokines. Understanding the response in microglia might contribute to the knowledge of neuroinflammatory diseases in general and hopefully prove Sortilin as a potential drug target in the development of future treatments for neuropathic pain.

M3 - Conference abstract for conference

Y2 - 2 July 2016 through 6 July 2016

ER -